Short Description

NGS genetic DNA test detecets for variant and mutation detection in ZFYVE27 gene for SPG33

PreTest Information

Clinical History of Patient who is going for ZFYVE27 Gene SPG33 NGS Genetic DNA Test A Genetic Counselling session to draw a pedigree chart of family members affected with ZFYVE27 Gene SPG33

Detail Description

ZFYVE27 Gene SPG33 NGS Genetic DNA Test: Symptoms, Diagnosis, and Cost

SPG33 is a type of hereditary spastic paraplegia (HSP), which is a group of neurological disorders characterized by progressive stiffness and weakness in the legs. The ZFYVE27 gene has been identified as a cause of SPG33. This gene provides instructions for making a protein called spastizin, which is involved in the development and maintenance of nerve cells.

Symptoms of SPG33

The symptoms of SPG33 typically begin in childhood or early adulthood and progress slowly over time. The condition can cause:

• Stiffness and weakness in the legs
• Difficulty walking or running
• Loss of balance
• Uncontrollable muscle spasms
• Difficulty with fine motor skills, such as writing or buttoning clothes
• Bladder and bowel dysfunction

Diagnosis of SPG33

The diagnosis of SPG33 is typically made through a combination of clinical evaluation, genetic testing, and imaging studies. A neurological exam can help identify the characteristic symptoms of the condition, and imaging studies such as MRI can help rule out other possible causes of the symptoms.

Genetic testing is the most definitive way to diagnose SPG33. The ZFYVE27 gene can be analyzed using next-generation sequencing (NGS) technology, which can identify mutations in the gene that are associated with the condition.

The Cost of SPG33 Genetic Testing

The cost of SPG33 genetic testing can vary depending on the specific laboratory that performs the test. At DNA Labs India, the cost of NGS-based genetic testing for the ZFYVE27 gene is INR 20,000. This includes the cost of sample collection, DNA extraction, sequencing, and analysis.

It is important to note that genetic testing may not be covered by insurance, and patients should check with their insurance provider to determine coverage and out-of-pocket costs.

Conclusion

SPG33 is a rare genetic disorder that can cause significant disability over time. Early diagnosis through genetic testing can help patients and their families better understand the condition and plan for appropriate care and management. The cost of NGS-based genetic testing for the ZFYVE27 gene at DNA Labs India is INR 20,000.

At DNA Labs India, we are committed to providing accurate and reliable genetic testing services to patients and healthcare providers. Contact us today to learn more about our services and how we can help you.

Before getting tested ask for Raw Data, FASTQ, and VCF files along with clinical test report from DNA Testing Lab. DNA Labs India is the Only lab that is transparent and will share Raw Data, FASTQ, and VCF files along with the conclusive clinical report for ZFYVE27 Gene SPG33 NGS Genetic DNA Test