Short Description

NGS genetic DNA test detecets for variant and mutation detection in ZDHHC17 gene for Huntington disease, ZDHHC17 related

PreTest Information

Clinical History of Patient who is going for ZDHHC17 Gene Huntington disease, ZDHHC17 related NGS Genetic DNA Test A Genetic Counselling session to draw a pedigree chart of family members affected with ZDHHC17 Gene Huntington disease, ZDHHC17 related

Detail Description

ZDHHC17 Gene and its Relation to Huntington Disease: A Comprehensive Guide

Huntington disease is a genetic disorder that affects the brain, causing progressive movement, cognitive, and psychiatric symptoms. It is caused by a mutation in the huntingtin (HTT) gene, which codes for a protein that is essential for the development and function of nerve cells.

However, recent research has shown that another gene, called ZDHHC17, may also play a role in the development of Huntington disease. In this blog post, we will explore the connection between the ZDHHC17 gene and Huntington disease, as well as how DNA Labs India offers ZDHHC17-related NGS genetic DNA tests to diagnose the disease.

The ZDHHC17 Gene and Huntington Disease

The ZDHHC17 gene is located on chromosome 12 and codes for a protein called palmitoyltransferase ZDHHC17. This protein is involved in the process of palmitoylation, which is the addition of a fatty acid called palmitate to proteins. Palmitoylation is important for the proper functioning of proteins in nerve cells.

Recent studies have shown that mutations in the ZDHHC17 gene may be associated with the development of Huntington disease. Specifically, these mutations may affect the palmitoylation of the HTT protein, leading to its accumulation and the formation of toxic clumps in the brain.

While the exact mechanism by which ZDHHC17 mutations contribute to Huntington disease is not fully understood, researchers believe that it may be related to the disruption of the normal functioning of nerve cells in the brain.

ZDHHC17-Related NGS Genetic DNA Test for Huntington Disease

At DNA Labs India, we offer ZDHHC17-related NGS genetic DNA tests to diagnose Huntington disease. This test uses next-generation sequencing (NGS) technology to analyze the DNA sequence of the ZDHHC17 gene and identify any mutations that may be associated with the disease.

The cost of the ZDHHC17-related NGS genetic DNA test for Huntington disease is INR 20,000.

Symptoms and Diagnosis of Huntington Disease

The symptoms of Huntington disease can vary widely depending on the stage of the disease and the individual. However, some common symptoms include:

• Uncontrolled movements, such as jerking or twitching
• Difficulty with balance and coordination
• Changes in mood and personality
• Cognitive decline, such as difficulty with memory and decision-making

Diagnosis of Huntington disease typically involves a combination of genetic testing, neurological evaluation, and imaging studies. Genetic testing can identify the mutation in the HTT gene that causes the disease, while neurological evaluation and imaging studies can assess the extent of brain damage and the progression of the disease.

Conclusion

The ZDHHC17 gene may play a role in the development of Huntington disease, and DNA Labs India offers ZDHHC17-related NGS genetic DNA tests to diagnose the disease. If you or a loved one is experiencing symptoms of Huntington disease, it is important to seek medical evaluation and genetic testing to ensure accurate diagnosis and appropriate treatment.

Before getting tested ask for Raw Data, FASTQ, and VCF files along with clinical test report from DNA Testing Lab. DNA Labs India is the Only lab that is transparent and will share Raw Data, FASTQ, and VCF files along with the conclusive clinical report for ZDHHC17 Gene Huntington disease, ZDHHC17 related NGS Genetic DNA Test