Short Description

Warfarin is a Coumarin-based anticoagulant drug used to prevent thrombosis due to inherited and acquired hemostatic disorders. It is also used in other conditions like atrial fibrillation and hip replacement surgery. Warfarin therapy has one of the highest rates of severe reactions. Its metabolism is highly variable and dependent upon genetic factors. Variants within 3 genes and 1 intragenic locus are known to affect the metabolism of Warfarin.The CYP2C9 gene encodes the enzyme which primarily metabolizes the more active isomer of Warfarin to inactive products. Some CYP2C9 variants result in decreased enzymatic activity and may lead to increase in serum levels and over-medication. The decreased expression of VKORC1 gene, results in reduced availability of vitamin K. This may also increase serum Warfarin and lead to overmedication, driving the INR above the therapeutic target.

PreTest Information

No special preparation required

Detail Description

WARFARIN SENSITIVITY DETECTION Test

Warfarin is a commonly prescribed anticoagulant medication that is used to prevent blood clots. However, some people may have a genetic sensitivity to warfarin, which can cause them to be more susceptible to bleeding or have a higher risk of blood clots. It is therefore important to identify these individuals through a Warfarin Sensitivity Detection Test.

Symptoms of Warfarin Sensitivity

Some common symptoms of warfarin sensitivity include:

• Unexplained bruising or bleeding
• Blood in the urine or stool
• Excessive bleeding from cuts or wounds
• Headaches or dizziness
• Shortness of breath

If you experience any of these symptoms while taking warfarin, it is important to speak with your healthcare provider immediately.

Diagnosis of Warfarin Sensitivity

The Warfarin Sensitivity Detection Test is a genetic test that can identify individuals who may have a sensitivity to warfarin. The test analyzes a person's DNA to determine if they have any genetic variants that may affect their response to the medication. The test is typically performed using a blood sample and can be ordered by a healthcare provider.

Cost of Warfarin Sensitivity Detection Test

The cost of the Warfarin Sensitivity Detection Test in India is INR 19,000. However, the cost may vary depending on the healthcare provider and the location of the testing facility.

Conclusion

If you are taking warfarin, it is important to be aware of the potential for sensitivity and to speak with your healthcare provider if you experience any symptoms. The Warfarin Sensitivity Detection Test can help identify individuals who may be at risk and allow for personalized treatment plans to be developed. If you are interested in getting tested, speak with your healthcare provider to learn more.

Warfarin is a Coumarin-based anticoagulant drug used to prevent thrombosis due to inherited and acquired hemostatic disorders. It is also used in other conditions like atrial fibrillation and hip replacement surgery. Warfarin therapy has one of the highest rates of severe reactions. Its metabolism is highly variable and dependent upon genetic factors. Variants within 3 genes and 1 intragenic locus are known to affect the metabolism of Warfarin.The CYP2C9 gene encodes the enzyme which primarily metabolizes the more active isomer of Warfarin to inactive products. Some CYP2C9 variants result in decreased enzymatic activity and may lead to increase in serum levels and over-medication. The decreased expression of VKORC1 gene, results in reduced availability of vitamin K. This may also increase serum Warfarin and lead to overmedication, driving the INR above the therapeutic target.