Short Description

NGS genetic DNA test detecets for variant and mutation detection in USF1 gene for Hyperlipidemia, familial combined, susceptibility to

PreTest Information

Clinical History of Patient who is going for USF1 Gene Hyperlipidemia, familial combined, susceptibility to NGS Genetic DNA Test A Genetic Counselling session to draw a pedigree chart of family members affected with Hyperlipidemia, familial combined, susceptibility to

Detail Description

Understanding USF1 Gene Hyperlipidemia and Its Susceptibility to NGS Genetic DNA Test

Hyperlipidemia is a condition characterized by high levels of lipids or fats in the blood. It is a major risk factor for cardiovascular diseases and is known to have a genetic component. Familial combined hyperlipidemia (FCH) is a common form of hyperlipidemia that is inherited in an autosomal dominant pattern. It is caused by mutations in genes that regulate lipid metabolism, including the USF1 gene.

The Role of USF1 Gene in Hyperlipidemia

The USF1 gene is located on chromosome 1 and encodes a protein that regulates the expression of several other genes involved in lipid metabolism. It is known to play a crucial role in the regulation of cholesterol and triglyceride levels in the blood. Mutations in the USF1 gene have been associated with an increased risk of FCH and other forms of hyperlipidemia.

Symptoms of FCH

FCH is usually asymptomatic and is often detected during routine blood tests. However, some individuals with FCH may experience symptoms such as:

• Chest pain
• Shortness of breath
• Fatigue
• Xanthomas (yellowish deposits of cholesterol under the skin)

Diagnosis of FCH

FCH is usually diagnosed based on the results of a lipid profile test. This test measures the levels of various lipids in the blood, including total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides. Individuals with FCH typically have elevated levels of these lipids.

NGS Genetic DNA Test for FCH

Next-generation sequencing (NGS) is a powerful technique that allows for the simultaneous analysis of multiple genes associated with FCH and other forms of hyperlipidemia. The NGS genetic DNA test for FCH can identify mutations in the USF1 gene and other genes involved in lipid metabolism that may be responsible for the condition.

Cost of NGS Genetic DNA Test in India

The cost of the NGS genetic DNA test for FCH in India varies depending on the laboratory and the specific test requested. On average, the cost of the test ranges from INR 15,000 to INR 25,000.

Conclusion

FCH is a common form of hyperlipidemia that is caused by mutations in genes involved in lipid metabolism, including the USF1 gene. The NGS genetic DNA test is a powerful tool for identifying these mutations and diagnosing FCH. If you suspect that you or a loved one may be at risk for FCH, speak to your healthcare provider about the possibility of undergoing genetic testing.

For more information on genetic testing for hyperlipidemia and other genetic conditions, contact DNA Labs India.