Short Description

Genetic variants in UGT1A1 may cause reduced or absent UGT1A1 enzymatic activity, resulting in conditions associated with unconjugated hyperbilirubinemia including Gilbert syndrome and Crigler-Najjar syndromes types I and II. Gilbert syndrome is the most common hereditary cause of increased bilirubin. This assay also helps in identifying individuals who are at increased risk of adverse reactions with drugs that are metabolized by UGT1A1 including Irinotecan, Atazanavir, Nilotinib, Pazopanib and Belinostat.

PreTest Information

No special preparation required

Detail Description

UGT1A1 Gene Polymorphism (Nucleotide 'TA' Repeats) Detection Test Cost

DNA Labs India offers a UGT1A1 Gene Polymorphism (Nucleotide 'TA' Repeats) Detection Test for INR 7500. This test helps in identifying genetic variations that may affect an individual's ability to metabolize certain medications and toxins.

Symptoms

UGT1A1 gene polymorphism is associated with a range of symptoms, including:

• Jaundice
• Fever
• Abdominal pain
• Dark urine
• Fatigue
• Loss of appetite

These symptoms may be indicative of a condition called Gilbert's syndrome, which is caused by a reduced ability of the liver to process bilirubin.

Diagnosis

The UGT1A1 gene polymorphism can be diagnosed using a genetic test that detects the presence of the nucleotide 'TA' repeats. The test involves taking a sample of blood or saliva and analyzing the DNA for the specific genetic variations.

Individuals who have a UGT1A1 gene polymorphism may be at increased risk of developing Gilbert's syndrome or experiencing adverse reactions to certain medications, including chemotherapy drugs and anesthesia.

Conclusion

The UGT1A1 Gene Polymorphism (Nucleotide 'TA' Repeats) Detection Test offered by DNA Labs India is a valuable tool for identifying genetic variations that may affect an individual's ability to metabolize certain medications and toxins. With a cost of INR 7500, the test is affordable and accessible to individuals who are concerned about their genetic risk factors.

If you are experiencing symptoms of Gilbert's syndrome or have a family history of the condition, it is recommended to speak with a healthcare provider about getting tested for the UGT1A1 gene polymorphism.

At DNA Labs India, we are committed to providing accurate and reliable genetic testing services to help individuals make informed decisions about their health. Contact us today to learn more about our UGT1A1 Gene Polymorphism (Nucleotide 'TA' Repeats) Detection Test.

Genetic variants in UGT1A1 may cause reduced or absent UGT1A1 enzymatic activity, resulting in conditions associated with unconjugated hyperbilirubinemia including Gilbert syndrome and Crigler-Najjar syndromes types I and II. Gilbert syndrome is the most common hereditary cause of increased bilirubin. This assay also helps in identifying individuals who are at increased risk of adverse reactions with drugs that are metabolized by UGT1A1 including Irinotecan, Atazanavir, Nilotinib, Pazopanib and Belinostat.