Short Description

Measurement of TPMT activity is encouraged prior to commencing the treatment of patients with Thiopurine drugs such as Azathioprine, 6-Mercaptopurine and 6-Thioguanine. Patients with low or absent activity are at a heightened risk of drug-induced bone marrow toxicity due to accumulation of the unmetabolised drug.

PreTest Information

Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory.

Detail Description

TPMT (THIOPURINE METHYL TRANSFERASE) GENOTYPING Test Cost in India: Symptoms, Diagnosis

TPMT (Thiopurine Methyl Transferase) Genotyping is a test that is used to determine the genetic makeup of an individual's TPMT enzyme. This enzyme is responsible for breaking down certain medications, including thiopurine drugs that are used to treat inflammatory bowel disease and leukemia. The test can help doctors determine the appropriate dosage of these medications for a patient based on their TPMT enzyme activity.

What are the Symptoms of TPMT Deficiency?

TPMT deficiency can lead to an increased risk of toxicity from thiopurine drugs, which can cause a range of symptoms including:

• Nausea
• Vomiting
• Diarrhea
• Fever
• Jaundice
• Unexplained bruising or bleeding
• Fatigue

If you experience any of these symptoms while taking thiopurine drugs, it is important to speak with your doctor immediately.

How is TPMT Deficiency Diagnosed?

TPMT deficiency can be diagnosed through a blood test that measures the activity of the TPMT enzyme. A TPMT Genotyping test can also be used to determine an individual's genetic makeup and predict their likelihood of having TPMT deficiency.

What is the Cost of TPMT Genotyping Test in India?

The cost of TPMT Genotyping test in India can vary depending on the location and lab where the test is performed. On average, the cost of TPMT Genotyping test in India is around INR 7,200.

Why is TPMT Genotyping Test Important?

TPMT Genotyping test is important for individuals who are prescribed thiopurine drugs for the treatment of inflammatory bowel disease or leukemia. This test can help doctors determine the appropriate dosage of the medication based on an individual's TPMT enzyme activity. This can help reduce the risk of toxicity and ensure that the medication is effective in treating the condition.

Conclusion

TPMT Genotyping test is a valuable tool for individuals who are prescribed thiopurine drugs for the treatment of inflammatory bowel disease or leukemia. The test can help doctors determine the appropriate dosage of the medication based on an individual's TPMT enzyme activity, which can reduce the risk of toxicity and ensure that the medication is effective in treating the condition. If you experience any symptoms of TPMT deficiency while taking thiopurine drugs, it is important to speak with your doctor immediately.

At DNA Labs India, we offer TPMT Genotyping test at an affordable cost. Contact us today to learn more about this test and how it can benefit you.

Measurement of TPMT activity is encouraged prior to commencing the treatment of patients with Thiopurine drugs such as Azathioprine, 6-Mercaptopurine and 6-Thioguanine. Patients with low or absent activity are at a heightened risk of drug-induced bone marrow toxicity due to accumulation of the unmetabolised drug.