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TNFRSF11B Gene Paget disease, juvenile NGS Genetic DNA Test Details
Understanding TNFRSF11B Gene and Paget Disease in Juvenile
Paget disease is a rare bone disorder that affects the way bones break down and rebuild. It is characterized by abnormal bone remodeling that can cause bone pain, deformity, and fractures. While the exact cause of Paget disease is unknown, genetic mutations are believed to play a role in its development.
The TNFRSF11B gene, also known as OPG or osteoprotegerin, is one of the genes that have been identified as a risk factor for Paget disease. This gene provides instructions for producing a protein that regulates bone remodeling by inhibiting the activity of cells that break down bone tissue. Mutations in the TNFRSF11B gene can disrupt the normal function of the protein, leading to abnormal bone remodeling and the development of Paget disease.
Symptoms of Paget Disease
The symptoms of Paget disease can vary widely depending on the severity and location of the bone involvement. Some people with Paget disease may have no symptoms at all, while others may experience:
- Bone pain and tenderness
- Bone deformity and enlargement
- Frequent fractures
- Joint pain and stiffness
- Nerve compression
- Hearing loss and tinnitus
- Headaches and dizziness
Diagnosis of Paget Disease
Diagnosis of Paget disease typically involves a combination of physical examination, medical history, and imaging studies such as X-rays, CT scans, and bone scans. Blood tests may also be performed to check for elevated levels of certain bone markers that are indicative of Paget disease.
NGS Genetic DNA Test for TNFRSF11B Gene
A Next-Generation Sequencing (NGS) genetic DNA test can be performed to identify mutations in the TNFRSF11B gene that are associated with Paget disease. This test uses advanced sequencing technologies to analyze the entire coding region of the TNFRSF11B gene and identify any genetic variations that may be present.
Cost of NGS Genetic DNA Test for TNFRSF11B Gene
The cost of NGS genetic DNA testing for TNFRSF11B gene can vary depending on the testing laboratory and the specific tests included in the panel. On average, the cost of NGS genetic DNA testing for TNFRSF11B gene in India ranges from INR 15,000 to INR 25,000.
Conclusion
Paget disease is a rare bone disorder that can cause significant pain and disability. While the exact cause of the disease is unknown, genetic mutations are believed to play a role in its development. The TNFRSF11B gene is one of the genes that have been identified as a risk factor for Paget disease. NGS genetic DNA testing can be performed to identify mutations in the TNFRSF11B gene that are associated with Paget disease. If you are experiencing symptoms of Paget disease or have a family history of the disease, it is important to speak with your doctor about genetic testing options.
At DNA Labs India, we offer a comprehensive range of genetic testing services, including NGS genetic DNA testing for TNFRSF11B gene. Contact us today to learn more about our services and how we can help you gain insights into your genetic health.
