Short Description

NGS genetic DNA test detecets for variant and mutation detection in TGFBR2 gene for Colorectal cancer, hereditary nonpolyposis type 6

PreTest Information

Clinical History of Patient who is going for TGFBR2 Gene Colorectal cancer, hereditary nonpolyposis type 6 NGS Genetic DNA Test. A Genetic Counselling session to draw a pedigree chart of family members affected with TGFBR2 Gene Colorectal cancer, hereditary nonpolyposis type 6 NGS Genetic DNA Test gene TGFBR2

Detail Description

TGFBR2 Gene and Colorectal Cancer: Understanding Hereditary Nonpolyposis Type 6

Colorectal cancer is one of the most common types of cancer worldwide. In India, it is the third most common cancer among men and the second most common cancer among women. While most cases of colorectal cancer are sporadic, meaning they occur without a clear cause, some cases are hereditary and linked to genetic mutations.

One such genetic mutation is in the TGFBR2 gene, which is associated with hereditary nonpolyposis type 6 (HNPCC6) colorectal cancer. Understanding this gene and its implications can help individuals and families take proactive steps to prevent and manage this type of cancer.

The TGFBR2 Gene

The TGFBR2 gene provides instructions for making a protein called the transforming growth factor-beta receptor 2. This protein is involved in regulating cell growth and division, as well as other cellular processes such as cell differentiation and apoptosis (programmed cell death).

When the TGFBR2 gene is mutated, it can interfere with the normal functioning of the protein and lead to uncontrolled cell growth and division, which can result in cancer.

HNPCC6 Colorectal Cancer

HNPCC6 is a hereditary form of colorectal cancer that is linked to mutations in the TGFBR2 gene. Individuals with this type of cancer have a higher risk of developing cancer in other organs, such as the endometrium, ovary, stomach, pancreas, and urinary tract.

Some of the common symptoms of HNPCC6 colorectal cancer include:

• Changes in bowel habits, such as diarrhea or constipation
• Blood in the stool
• Abdominal pain or cramping
• Unexplained weight loss

Diagnosis of HNPCC6 colorectal cancer involves a combination of medical history, physical examination, and tests such as colonoscopy, biopsy, and genetic testing.

NGS Genetic DNA Test for TGFBR2 Gene

NGS (Next-Generation Sequencing) genetic testing is a powerful tool that can help diagnose genetic mutations in the TGFBR2 gene. This test involves analyzing a person's DNA to look for specific changes or mutations that can increase their risk of developing HNPCC6 colorectal cancer.

The cost of the NGS genetic DNA test for the TGFBR2 gene in India is typically around INR 20,000.

Conclusion

Understanding the role of the TGFBR2 gene in hereditary nonpolyposis type 6 colorectal cancer can help individuals and families take proactive steps to prevent and manage this type of cancer. If you or a loved one has a family history of colorectal cancer or other related cancers, it may be worth considering genetic testing to determine your risk and develop a personalized prevention plan.

At DNA Labs India, we offer a range of genetic testing services, including NGS genetic DNA testing for the TGFBR2 gene. Contact us today to learn more about our services and how we can help you take control of your health.