Short Description

NGS genetic DNA test detecets for variant and mutation detection in TARDBP gene for Amyotrophic lateral sclerosis type 10

PreTest Information

Clinical History of Patient who is going for TARDBP Gene Amyotrophic lateral sclerosis type 10 NGS Genetic DNA Test A Genetic Counselling session to draw a pedigree chart of family members affected with TARDBP Gene Amyotrophic lateral sclerosis type 10

Detail Description

TARDBP Gene and Amyotrophic Lateral Sclerosis Type 10: Understanding the NGS Genetic DNA Test

Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease, is a progressive neurodegenerative disorder that affects nerve cells in the brain and spinal cord. The disease is characterized by the gradual loss of muscle control, leading to difficulty in speaking, swallowing, and breathing.

ALS is caused by a combination of genetic and environmental factors, with around 10% of cases being inherited. One of the genes associated with ALS is the TARDBP gene, which provides instructions for making a protein called TAR DNA-binding protein 43 (TDP-43).

In some cases, mutations in the TARDBP gene can lead to the development of ALS type 10, a rare subtype of the disease that accounts for less than 1% of all cases. ALS type 10 is typically characterized by an earlier onset of symptoms, with patients experiencing muscle weakness and atrophy in their arms and legs, as well as difficulty with speech and swallowing.

NGS Genetic DNA Test for TARDBP Gene

NGS (Next-Generation Sequencing) is a cutting-edge technology that allows for the rapid and accurate analysis of DNA sequences. The NGS Genetic DNA Test for the TARDBP gene can help to identify mutations that are associated with ALS type 10.

The NGS Genetic DNA Test for the TARDBP gene involves the analysis of a patient's DNA sample, which can be obtained through a simple blood test or cheek swab. The sample is then sent to a specialized laboratory, where it is analyzed using NGS technology to identify any mutations in the TARDBP gene.

Symptoms and Diagnosis of ALS Type 10

The symptoms of ALS type 10 are similar to those of other forms of ALS, including muscle weakness, atrophy, and difficulty with speech and swallowing. However, ALS type 10 tends to have an earlier onset and a more rapid progression than other forms of the disease.

Diagnosis of ALS type 10 typically involves a combination of clinical evaluation and genetic testing. A neurologist will perform a physical exam and may order additional tests such as electromyography (EMG) and nerve conduction studies to assess muscle function.

If ALS type 10 is suspected, genetic testing may be recommended to identify any mutations in the TARDBP gene. This can help to confirm the diagnosis and provide valuable information for treatment and management of the disease.

Cost of NGS Genetic DNA Test for TARDBP Gene

The cost of the NGS Genetic DNA Test for the TARDBP gene can vary depending on the laboratory and location. In India, the cost of the test is typically around INR 20,000.

While the cost of genetic testing may seem high, it is important to consider the potential benefits. Early diagnosis of ALS type 10 can help to improve patient outcomes and provide valuable information for treatment and management of the disease.

Conclusion

The NGS Genetic DNA Test for the TARDBP gene can help to identify mutations associated with ALS type 10, a rare subtype of the disease that accounts for less than 1% of all cases. Early diagnosis of ALS type 10 can help to improve patient outcomes and provide valuable information for treatment and management of the disease. While the cost of genetic testing may seem high, the potential benefits make it a valuable tool for patients and healthcare providers.

At DNA Labs India, we offer a range of genetic testing services, including the NGS Genetic DNA Test for the TARDBP gene. Our team of experts is dedicated to providing accurate and reliable testing services to help improve patient outcomes. Contact us today to learn more about our services and how we can help you.

Before getting tested ask for Raw Data, FASTQ, and VCF files along with clinical test report from DNA Testing Lab. DNA Labs India is the Only lab that is transparent and will share Raw Data, FASTQ, and VCF files along with the conclusive clinical report for TARDBP Gene Amyotrophic lateral sclerosis type 10 NGS Genetic DNA Test