Short Description

This translocation results in the MLL- AF4 fusion gene and is associated with a poor outcome. It is found in >80% cases of infant ALL and is the most frequent MLL translocation in ALL but is rarely seen in AML.

PreTest Information

Clinical history is mandatory.

Detail Description

DNA Labs India: MLL-AF4 PCR Qualitative Test Cost and Symptoms Diagnosis

MLL-AF4 PCR Qualitative Test is a diagnostic test that detects the presence of t(411) (q21q23) (MLL-AF4) gene fusion in patients suspected of having acute lymphoblastic leukemia (ALL). DNA Labs India offers this test at an affordable cost of INR 5000.

What is t(411) (q21q23) (MLL-AF4) gene fusion?

t(411) (q21q23) (MLL-AF4) gene fusion is a genetic abnormality that occurs when two genes, MLL and AF4, fuse together. This fusion results in the production of a protein that can cause the uncontrolled growth of immature white blood cells, leading to the development of ALL.

What are the symptoms of ALL?

The symptoms of ALL can vary from person to person and may include:

• Fever
• Fatigue
• Weakness
• Loss of appetite
• Weight loss
• Bone pain
• Joint pain
• Swollen lymph nodes
• Easy bruising or bleeding
• Frequent infections

How is ALL diagnosed?

The diagnosis of ALL typically involves a combination of tests, including:

• Complete blood count (CBC)
• Bone marrow biopsy
• Cytogenetic analysis
• Immunophenotyping
• MLL-AF4 PCR Qualitative Test

What is MLL-AF4 PCR Qualitative Test?

The MLL-AF4 PCR Qualitative Test is a highly sensitive and specific diagnostic test that detects the presence of t(411) (q21q23) (MLL-AF4) gene fusion. This test involves the use of polymerase chain reaction (PCR) technology to amplify and detect the fusion gene.

How is the MLL-AF4 PCR Qualitative Test performed?

The MLL-AF4 PCR Qualitative Test is performed on a blood or bone marrow sample. The sample is collected by a healthcare professional and sent to the laboratory for analysis. The laboratory technicians extract the DNA from the sample and use PCR technology to amplify and detect the MLL-AF4 fusion gene.

What is the cost of MLL-AF4 PCR Qualitative Test?

DNA Labs India offers the MLL-AF4 PCR Qualitative Test at an affordable cost of INR 5000.

Conclusion

MLL-AF4 PCR Qualitative Test is a highly sensitive and specific diagnostic test that detects the presence of t(411) (q21q23) (MLL-AF4) gene fusion in patients suspected of having ALL. The test is performed on a blood or bone marrow sample and is offered by DNA Labs India at an affordable cost of INR 5000. If you or your loved one is experiencing any of the symptoms of ALL, it is important to consult a healthcare professional and undergo appropriate diagnostic tests.

For more information or to schedule an appointment, please contact DNA Labs India.

This translocation results in the MLL- AF4 fusion gene and is associated with a poor outcome. It is found in >80% cases of infant ALL and is the most frequent MLL translocation in ALL but is rarely seen in AML.