Short Description

NGS genetic DNA test detecets for variant and mutation detection in SORL1 gene for Alzheimers disease, early onset, autosomal dominant

PreTest Information

Clinical History of Patient who is going for SORL1 Gene Alzheimers disease, early onset, autosomal dominant NGS Genetic DNA Test A Genetic Counselling session to draw a pedigree chart of family members affected with SORL1 Gene Alzheimers disease, early onset, autosomal dominant

Detail Description

SORL1 Gene and Alzheimer's Disease: Early Onset, Autosomal Dominant

Alzheimer's disease is a progressive neurological disorder that affects millions of people worldwide. It is characterized by memory loss, cognitive decline, and changes in behavior. While Alzheimer's is typically associated with older adults, there is also a rare form of the disease that can affect individuals as early as their 30s or 40s. This form of Alzheimer's is known as early-onset familial Alzheimer's disease (EOFAD) and is caused by mutations in specific genes.

One of the genes associated with EOFAD is the SORL1 gene. SORL1 stands for sortilin-related receptor with LDLR class A repeats and is involved in the transport and clearance of amyloid beta, a protein that accumulates in the brains of individuals with Alzheimer's disease. Mutations in the SORL1 gene can lead to a buildup of amyloid beta and contribute to the development of Alzheimer's disease.

Diagnosing SORL1 Gene Mutations

If you have a family history of early-onset Alzheimer's disease, it may be worth considering genetic testing to determine if you carry a mutation in the SORL1 gene. Next-generation sequencing (NGS) is a type of genetic testing that can analyze multiple genes at once, including SORL1. NGS testing can identify mutations in SORL1 that may increase your risk of developing Alzheimer's disease.

Symptoms of Early-Onset Alzheimer's Disease

The symptoms of early-onset Alzheimer's disease are similar to those of late-onset Alzheimer's disease and may include:

• Memory loss
• Difficulty with problem-solving or planning
• Difficulty completing familiar tasks
• Confusion about time or place
• Changes in mood or personality

If you are experiencing any of these symptoms and have a family history of Alzheimer's disease, it is important to speak with your healthcare provider about genetic testing and other diagnostic options.

The Cost of Genetic Testing for SORL1 Mutations

The cost of NGS testing for SORL1 mutations can vary depending on the testing provider and the specific test ordered. At DNA Labs India, we offer NGS testing for SORL1 mutations for INR 20,000. This test includes analysis of the entire SORL1 gene and can identify mutations that may increase your risk of developing Alzheimer's disease.

Conclusion

Early-onset Alzheimer's disease is a rare but devastating form of the disease that can impact individuals at a younger age. Mutations in the SORL1 gene are one of the genetic causes of early-onset Alzheimer's disease. If you have a family history of early-onset Alzheimer's disease or are experiencing symptoms of the disease, it may be worth considering genetic testing for SORL1 mutations. At DNA Labs India, we offer NGS testing for SORL1 mutations for INR 20,000, which can help identify mutations that may increase your risk of developing Alzheimer's disease.

It is important to speak with your healthcare provider about diagnostic options and to develop a personalized plan for managing your risk of developing Alzheimer's disease.

For more information on genetic testing for Alzheimer's disease and other genetic conditions, contact DNA Labs India today.

Before getting tested ask for Raw Data, FASTQ, and VCF files along with clinical test report from DNA Testing Lab. DNA Labs India is the Only lab that is transparent and will share Raw Data, FASTQ, and VCF files along with the conclusive clinical report for SORL1 Gene Alzheimers disease, early onset, autosomal dominant NGS Genetic DNA Test