Short Description

NGS genetic DNA test detecets for variant and mutation detection in SDHD gene for Paraganglioma and gastric stromal sarcoma

PreTest Information

Clinical History of Patient who is going for SDHD Gene Paraganglioma and gastric stromal sarcoma NGS Genetic DNA Test. A Genetic Counselling session to draw a pedigree chart of family members affected with SDHD Gene Paraganglioma and gastric stromal sarcoma NGS Genetic DNA Test gene SDHD

Detail Description

SDHD Gene Paraganglioma and Gastric Stromal Sarcoma NGS Genetic DNA Test

Paraganglioma and gastric stromal sarcoma are two types of tumors that are often associated with genetic mutations. In particular, mutations in the SDHD gene have been found to increase the risk of developing these tumors. SDHD gene testing is a genetic DNA test that can help identify mutations in this gene, allowing for earlier diagnosis and more effective treatment.

What is the SDHD Gene?

The SDHD gene is located on chromosome 11 and is responsible for producing a protein that is involved in the function of mitochondria, the energy-producing organelles in cells. Mutations in the SDHD gene can disrupt mitochondrial function and lead to the development of tumors, particularly paraganglioma and gastric stromal sarcoma.

What are Paraganglioma and Gastric Stromal Sarcoma?

Paraganglioma is a type of tumor that develops in the cells of the sympathetic nervous system, which controls the body's "fight or flight" response. These tumors can occur anywhere along the sympathetic nervous system, but are most commonly found in the adrenal gland or near the base of the skull. Symptoms of paraganglioma can include high blood pressure, headaches, sweating, and heart palpitations.

Gastric stromal sarcoma is a type of tumor that develops in the cells of the stomach's connective tissue. These tumors are often slow-growing and may not cause symptoms in the early stages. As they grow, symptoms can include abdominal pain, nausea, vomiting, and weight loss.

How is SDHD Gene Paraganglioma and Gastric Stromal Sarcoma NGS Genetic DNA Test Performed?

The SDHD gene test is a genetic DNA test that can be performed using a blood or saliva sample. The sample is sent to a laboratory for analysis, where technicians look for mutations in the SDHD gene. This test uses next-generation sequencing (NGS) technology, which allows for a more comprehensive analysis of the gene compared to traditional genetic testing methods.

What are the Symptoms of SDHD Gene Paraganglioma and Gastric Stromal Sarcoma?

The symptoms of paraganglioma and gastric stromal sarcoma can vary depending on the location and size of the tumor. Some common symptoms include:

• High blood pressure
• Headaches
• Sweating
• Heart palpitations
• Abdominal pain
• Nausea
• Vomiting
• Weight loss

How is SDHD Gene Paraganglioma and Gastric Stromal Sarcoma Diagnosed?

Diagnosis of paraganglioma and gastric stromal sarcoma typically involves a combination of imaging tests, such as CT scans or MRI, and biopsy to confirm the presence of a tumor. SDHD gene testing can help identify mutations in the gene that may be contributing to the development of the tumor.

What is the Cost of SDHD Gene Paraganglioma and Gastric Stromal Sarcoma NGS Genetic DNA Test?

The cost of SDHD gene testing can vary depending on the laboratory and location. In India, the cost of this test is typically around INR 20,000. It is important to check with your healthcare provider or insurance company to determine if this test is covered under your plan.

Conclusion

SDHD gene testing is a valuable tool for identifying mutations that may be contributing to the development of paraganglioma and gastric stromal sarcoma. Early diagnosis and treatment can improve outcomes for patients with these types of tumors. If you are experiencing symptoms or have a family history of these tumors, talk to your healthcare provider about whether SDHD gene testing may be right for you.

For more information on DNA testing and genetic counseling, contact DNA Labs India, a leading provider of genetic testing services in India.