Short Description

NGS genetic DNA test detecets for variant and mutation detection in RET gene for RET, selective sequencing of exons 5, 8, 10, 11 and 13-16

PreTest Information

Clinical History of Patient who is going for RET Gene RET, selective sequencing of exons 5, 8, 10, 11 and 13-16 NGS Genetic DNA Test. A Genetic Counselling session to draw a pedigree chart of family members affected with RET Gene RET, selective sequencing of exons 5, 8, 10, 11 and 13-16 NGS Genetic DNA Test gene RET

Detail Description

RET Gene: Selective Sequencing of Exons 5, 8, 10, 11 and 13-16 NGS Genetic DNA Test

Genetic testing has revolutionized the field of medicine, providing clinicians with valuable insights into an individual's health and potential risk for certain diseases. One such test is the RET gene selective sequencing of exons 5, 8, 10, 11 and 13-16 NGS genetic DNA test. This test helps in the diagnosis of certain genetic disorders associated with the RET gene. In this blog, we will discuss the RET gene, its associated disorders, and the importance of the RET gene selective sequencing test.

The RET Gene

The RET gene is located on chromosome 10 and provides instructions for making a protein called the RET receptor tyrosine kinase. The RET protein plays an important role in the development and maintenance of nerve cells, especially those in the enteric nervous system, which controls the movement of food through the digestive tract.

Disorders Associated with RET Gene Mutations

Several genetic disorders are associated with mutations in the RET gene, including:

• Multiple Endocrine Neoplasia Type 2 (MEN2)
• Medullary Thyroid Carcinoma (MTC)
• Hirschsprung Disease (HD)
• Phaeochromocytoma (PCC)

MEN2 is a rare genetic disorder that affects the endocrine system, causing tumors to develop in the thyroid gland and adrenal glands. MTC is a type of thyroid cancer that arises from the parafollicular cells, which produce a hormone called calcitonin. HD is a congenital disorder that affects the nerve cells in the large intestine, causing problems with bowel movements. PCC is a rare tumor that develops in the adrenal glands, causing overproduction of adrenaline and other hormones.

The RET Gene Selective Sequencing Test

The RET gene selective sequencing test is a genetic test that analyzes specific regions of the RET gene to detect mutations that may be associated with the above-mentioned disorders. The test analyzes exons 5, 8, 10, 11, and 13-16 of the RET gene using Next-Generation Sequencing (NGS) technology. NGS is a high-throughput sequencing method that enables the analysis of millions of DNA sequences simultaneously.

Symptoms and Diagnosis

The symptoms of disorders associated with RET gene mutations vary depending on the disorder. In MEN2, symptoms may include a lump or swelling in the neck, hoarseness, difficulty breathing, and diarrhea. In MTC, symptoms may include a lump or swelling in the neck, difficulty swallowing, hoarseness, and cough. In HD, symptoms may include constipation, abdominal swelling, and vomiting. In PCC, symptoms may include high blood pressure, headaches, sweating, and palpitations.

Diagnosis of these disorders usually involves a combination of physical examination, imaging tests, and genetic testing. The RET gene selective sequencing test can help confirm a diagnosis and provide valuable information for treatment and management.

Cost of the RET Gene Selective Sequencing Test

The cost of the RET gene selective sequencing test in India is INR 20,000. The test is available at DNA Labs India, a leading provider of genetic testing services in the country. DNA Labs India uses state-of-the-art NGS technology to ensure accurate and reliable results.

Conclusion

The RET gene selective sequencing test is a valuable tool for the diagnosis of genetic disorders associated with the RET gene. The test can provide important information for treatment and management of these disorders. If you or someone you know is experiencing symptoms associated with these disorders, it is important to seek medical attention and consider genetic testing. Contact DNA Labs India to learn more about the RET gene selective sequencing test and other genetic testing services.

Before getting tested ask for Raw Data, FASTQ, and VCF files along with clinical test report from DNA Testing Lab. DNA Labs India is the Only lab that is transparent and will share Raw Data, FASTQ, and VCF files along with the conclusive clinical report for RET Gene RET, selective sequencing of exons 5, 8, 10, 11 and 13-16 NGS Genetic DNA Test