Short Description

NGS genetic DNA test detecets for variant and mutation detection in PRKAG2 gene for Wolff -Parkinson-White syndrome

PreTest Information

Clinical History of Patient who is going for PRKAG2 Gene Wolff -Parkinson-White syndrome NGS Genetic DNA Test. A Genetic Counselling session to draw a pedigree chart of family members affected with PRKAG2 Gene Wolff -Parkinson-White syndrome NGS Genetic DNA Test gene PRKAG2

Detail Description

PRKAG2 Gene Wolff-Parkinson-White Syndrome NGS Genetic DNA Test Cost INR 20,000: Symptoms and Diagnosis

Wolff-Parkinson-White syndrome (WPW) is a rare genetic condition that affects the electrical system of the heart. It is caused by an abnormality in the PRKAG2 gene, which encodes the gamma-2 regulatory subunit of AMP-activated protein kinase (AMPK).

AMPK is a protein that plays a critical role in regulating the energy balance of cells. It is activated in response to energy depletion and helps to restore energy homeostasis by stimulating the uptake and utilization of glucose and fatty acids. In the heart, AMPK helps to maintain normal cardiac function by regulating the balance between glucose and fatty acid metabolism.

Symptoms of WPW Syndrome

People with WPW syndrome may experience a wide range of symptoms, ranging from mild to severe. The most common symptoms include:

• Palpitations (rapid or irregular heartbeat)
• Shortness of breath
• Chest pain
• Dizziness or lightheadedness
• Fainting (syncope)

These symptoms may occur spontaneously or during exercise or other physical activity. In some cases, WPW syndrome may be asymptomatic and only detected during routine medical testing.

Diagnosis of WPW Syndrome

WPW syndrome is typically diagnosed using a combination of medical history, physical examination, and diagnostic tests. The most commonly used diagnostic tests include:

• Electrocardiogram (ECG): This test records the electrical activity of the heart and can detect abnormalities in the heart rhythm.
• Echocardiogram: This test uses ultrasound waves to create images of the heart and can detect structural abnormalities.
• Holter monitor: This is a portable device that records the heart rhythm over a period of 24-48 hours.
• Electrophysiological study (EPS): This is an invasive test that involves the insertion of catheters into the heart to measure the electrical activity and identify the location of the abnormal pathway.

NGS Genetic DNA Test for WPW Syndrome

Next-generation sequencing (NGS) is a powerful genetic testing technology that can rapidly sequence large amounts of DNA. It is increasingly being used to diagnose genetic conditions, including WPW syndrome.

The PRKAG2 gene is included in many NGS panels that are designed to detect genetic mutations associated with WPW syndrome. These panels can detect both inherited and de novo mutations in the PRKAG2 gene.

The cost of an NGS genetic DNA test for WPW syndrome varies depending on the laboratory and the specific panel used. In India, the cost of an NGS test for WPW syndrome is typically around INR 20,000.

Conclusion

WPW syndrome is a rare genetic condition that can cause a wide range of symptoms, including palpitations, shortness of breath, chest pain, dizziness, and fainting. It is caused by an abnormality in the PRKAG2 gene, which encodes the gamma-2 regulatory subunit of AMPK. Diagnosis of WPW syndrome typically involves a combination of medical history, physical examination, and diagnostic tests, including electrocardiogram, echocardiogram, Holter monitor, and electrophysiological study. Next-generation sequencing is an increasingly popular genetic testing technology that can detect mutations in the PRKAG2 gene associated with WPW syndrome. The cost of an NGS genetic DNA test for WPW syndrome in India is typically around INR 20,000.

Before getting tested ask for Raw Data, FASTQ, and VCF files along with clinical test report from DNA Testing Lab. DNA Labs India is the Only lab that is transparent and will share Raw Data, FASTQ, and VCF files along with the conclusive clinical report for PRKAG2 Gene Wolff -Parkinson-White syndrome NGS Genetic DNA Test