Short Description

NGS genetic DNA test detecets for variant and mutation detection in POMC gene for Obesity, early-onset, susceptibility to

PreTest Information

Clinical History of Patient who is going for POMC Gene Obesity, early-onset, susceptibility to NGS Genetic DNA Test. A Genetic Counselling session to draw a pedigree chart of family members affected with POMC Gene Obesity, early-onset, susceptibility to NGS Genetic DNA Test gene POMC

Detail Description

POMC Gene Obesity: Early-Onset Susceptibility and NGS Genetic DNA Test Cost

Obesity has become a global epidemic, and it is estimated that by 2030, around 38% of the world's population will be overweight or obese. Obesity is a complex disease that is influenced by environmental and genetic factors. The POMC gene is one of the genes associated with obesity, and mutations in this gene have been linked to early-onset obesity.

What is the POMC Gene?

The POMC gene is located on chromosome 2 and is responsible for the production of pro-opiomelanocortin. This protein is processed into smaller peptides, including alpha-melanocyte-stimulating hormone (α-MSH), which plays a role in regulating appetite and energy expenditure. Mutations in the POMC gene can disrupt the production of α-MSH, leading to early-onset obesity.

Early-Onset Obesity and POMC Gene Mutations

Early-onset obesity is defined as obesity that develops before the age of 5. POMC gene mutations are one of the genetic causes of early-onset obesity. Studies have shown that individuals with POMC gene mutations have a higher BMI and a greater likelihood of developing obesity-related comorbidities, such as type 2 diabetes and cardiovascular disease.

Symptoms of POMC Gene Obesity

The symptoms of POMC gene obesity are similar to those of other forms of obesity and include:

• Increased body weight
• Increased body fat percentage
• Insatiable appetite
• Difficulty losing weight
• Early-onset of obesity

Diagnosis of POMC Gene Obesity

Diagnosis of POMC gene obesity can be done through genetic testing. Next-generation sequencing (NGS) genetic testing is a powerful tool for identifying mutations in the POMC gene. This type of testing can detect mutations in multiple genes simultaneously, making it a cost-effective and efficient way to diagnose genetic disorders.

NGS Genetic DNA Test Cost for POMC Gene Obesity

The cost of NGS genetic testing for POMC gene obesity in India is around INR 20,000. This cost may vary depending on the laboratory and the specific test ordered. It is important to note that genetic testing is not typically covered by insurance, so patients should be prepared to pay out of pocket for this type of testing.

Conclusion

POMC gene mutations are one of the genetic causes of early-onset obesity. Genetic testing, specifically NGS genetic testing, can be used to diagnose POMC gene obesity. The cost of NGS genetic testing for POMC gene obesity in India is around INR 20,000. Early diagnosis and intervention can help individuals with POMC gene obesity manage their weight and reduce the risk of obesity-related comorbidities.

At DNA Labs India, we provide comprehensive NGS genetic testing services for a wide range of genetic disorders, including POMC gene obesity. Contact us today to learn more about our services and how we can help you.