Short Description

Vast majority of cases of Acute Promyelocytic Leukemia (APL) have a translocation t(1517)(q22q12-21) which fuses the Promyelocytic gene (PML) on chromosome band 15q22 to the Retinoic acid receptor alpha (RARA) gene at 17q12-21. This assay is useful for montoring patients in which t(1517) (q22q12) has been detected.

PreTest Information

Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory.

Detail Description

PML RARA t(1517)(q22q12) GENE REARRANGEMENT QUANTITATIVE PCR Test

DNA Labs India is a leading diagnostic laboratory that offers a PML RARA t(1517)(q22q12) GENE REARRANGEMENT QUANTITATIVE PCR Test for the diagnosis of certain types of leukemia. The test is designed to detect the PML RARA gene rearrangement in the DNA of patients suspected to have acute promyelocytic leukemia (APL).

What is PML RARA t(1517)(q22q12) GENE REARRANGEMENT?

PML RARA t(1517)(q22q12) GENE REARRANGEMENT is a genetic abnormality that occurs in some cases of acute promyelocytic leukemia (APL). This genetic abnormality is caused by the fusion of two genes, PML and RARA, resulting in the formation of a new gene called PML RARA. This new gene produces a protein that can interfere with normal cell growth and division, leading to the development of APL.

What are the symptoms of APL?

The symptoms of APL may include:

• Unexplained bruising or bleeding
• Fatigue
• Fever
• Shortness of breath
• Loss of appetite
• Weight loss

If you experience any of these symptoms, it is important to consult a doctor as soon as possible.

How is APL diagnosed?

APL is diagnosed through a combination of tests, including:

• Physical examination and medical history
• Blood tests
• Bone marrow biopsy
• Genetic testing, such as the PML RARA t(1517)(q22q12) GENE REARRANGEMENT QUANTITATIVE PCR Test

The PML RARA t(1517)(q22q12) GENE REARRANGEMENT QUANTITATIVE PCR Test is a highly sensitive and specific test that can detect the PML RARA gene rearrangement in the DNA of patients suspected to have APL.

What is the cost of the PML RARA t(1517)(q22q12) GENE REARRANGEMENT QUANTITATIVE PCR Test?

The cost of the PML RARA t(1517)(q22q12) GENE REARRANGEMENT QUANTITATIVE PCR Test at DNA Labs India is INR 7500.

Conclusion

The PML RARA t(1517)(q22q12) GENE REARRANGEMENT QUANTITATIVE PCR Test is an important diagnostic tool for the detection of APL. If you are experiencing any of the symptoms associated with APL, it is important to consult a doctor as soon as possible and consider getting tested.

At DNA Labs India, we are committed to providing accurate and reliable diagnostic testing services to our patients. Contact us today to learn more about our PML RARA t(1517)(q22q12) GENE REARRANGEMENT QUANTITATIVE PCR Test and other diagnostic services.

Vast majority of cases of Acute Promyelocytic Leukemia (APL) have a translocation t(15;17)(q22;q12-21) which fuses the Promyelocytic gene (PML) on chromosome band 15q22 to the Retinoic acid receptor alpha (RARA) gene at 17q12-21. This assay is useful for montoring patients in which t(15;17) (q22;q12) has been detected.