4H Syndrome is a rare genetic disorder that affects the nervous system. It is caused by mutations in the POLR3A, POLR3B, and POLR1C genes and is characterized by four main symptoms:

• Hypomyelination with Atrophy of the Basal Ganglia and Cerebellum (HABC)
• Hypodontia (missing teeth)
• Hypogonadotropic Hypogonadism (reduced hormone production)
• Microcephaly (small head size)

The 4H Syndrome Test is a genetic test that uses Nx GEN SEQUENCING technology to analyze the patient's DNA for mutations in the POLR3A, POLR3B, and POLR1C genes. This test is offered by DNA Labs India at a cost of INR 23,400.

The symptoms of 4H Syndrome can vary greatly among affected individuals, but the most common symptoms are:

• Hypomyelination with Atrophy of the Basal Ganglia and Cerebellum (HABC): This is a neurological condition that affects the white matter of the brain. It can cause problems with movement, muscle tone, and balance.
• Hypodontia: This is a dental condition that causes missing teeth. It can affect both baby teeth and permanent teeth.
• Hypogonadotropic Hypogonadism: This is a hormonal condition that affects the reproductive system. It can cause delayed puberty, infertility, and other reproductive problems.
• Microcephaly: This is a condition in which the head size is smaller than normal. It can cause developmental delays and intellectual disabilities.

The diagnosis of 4H Syndrome involves a physical examination, medical history, and genetic testing. The Nx GEN SEQUENCING test offered by DNA Labs India provides accurate results and helps diagnose rare genetic disorders like 4H Syndrome.

If you suspect that you or someone you know may have 4H Syndrome, it is important to seek medical attention and genetic testing. DNA Labs India offers comprehensive genetic testing services that can provide accurate results and help diagnose rare genetic disorders.