Test Name	NR1H4 Gene Intrahepatic cholestasis of pregnancy, NR1H4 related NGS Genetic DNA Test
Test type	General Physician
Pre-test Information	Clinical History of Patient who is going for NR1H4 Gene Intrahepatic cholestasis of pregnancy, NR1H4 related NGS Genetic DNA Test. A Genetic Counselling session to draw a pedigree chart of family members affected with NR1H4 Gene Intrahepatic cholestasis of pregnancy, NR1H4 related NGS Genetic DNA Test gene NR1H4
Report Delivery	3 to 4 Weeks
Components
Price	₹ 20000
Method	NGS Technology

Short Description

NGS genetic DNA test detecets for variant and mutation detection in NR1H4 gene for Intrahepatic cholestasis of pregnancy, NR1H4 related

PreTest Information

Clinical History of Patient who is going for NR1H4 Gene Intrahepatic cholestasis of pregnancy, NR1H4 related NGS Genetic DNA Test. A Genetic Counselling session to draw a pedigree chart of family members affected with NR1H4 Gene Intrahepatic cholestasis of pregnancy, NR1H4 related NGS Genetic DNA Test gene NR1H4

Detail Description

Exploring NR1H4 Gene and Intrahepatic Cholestasis of Pregnancy

Introduction

Pregnancy is an exciting time for women, but it also comes with its own set of challenges. One of the most common complications during pregnancy is intrahepatic cholestasis of pregnancy (ICP), a liver disorder that affects pregnant women. This condition can cause significant discomfort and poses risks to both the mother and baby. However, recent advancements in genetic testing have made it possible to identify the underlying cause of ICP in some cases. The NR1H4 gene has been identified as one of the genes that play a role in the development of ICP. In this blog post, we will explore the NR1H4 gene, its association with ICP, symptoms, diagnosis, and the cost of NR1H4 related NGS genetic DNA test.

NR1H4 Gene and ICP

The NR1H4 gene codes for the farnesoid X receptor (FXR), a protein that plays an essential role in regulating bile acid synthesis and transport. Bile acids are produced in the liver and are necessary for the digestion and absorption of fats. However, in some cases, bile acids can build up in the liver and cause damage, leading to ICP. Research has shown that mutations in the NR1H4 gene can lead to abnormal bile acid regulation and contribute to the development of ICP. Furthermore, studies have shown that variations in the NR1H4 gene can also affect the severity of ICP symptoms.

Symptoms of ICP

ICP typically develops during the third trimester of pregnancy, although it can occur earlier. The most common symptoms of ICP include:

• Itching, particularly on the hands and feet
• Dark urine
• Pale stools
• Abdominal pain
• Loss of appetite
• Nausea and vomiting

If you experience any of these symptoms during pregnancy, it is essential to speak with your healthcare provider immediately. Early diagnosis and treatment can help prevent complications and ensure a healthy pregnancy.

Diagnosis of ICP

Diagnosing ICP typically involves a physical exam, blood tests, and a review of symptoms. Blood tests can help identify elevated levels of liver enzymes and bile acids, which are indicative of ICP. In some cases, a liver biopsy may be necessary to confirm the diagnosis.

NR1H4 Related NGS Genetic DNA Test Cost

NGS (Next-generation sequencing) is a powerful tool that can help identify genetic mutations associated with ICP. NR1H4-related NGS genetic DNA testing is available in India and costs approximately INR 20,000. This test involves collecting a sample of your DNA, typically through a blood test or cheek swab. The sample is then analyzed to identify any mutations in the NR1H4 gene that may contribute to the development of ICP. If a mutation is identified, your healthcare provider can develop a personalized treatment plan to manage symptoms and reduce the risk of complications.

Conclusion

Intrahepatic cholestasis of pregnancy can be a challenging condition to manage, but recent advancements in genetic testing have made it easier to identify the underlying cause of some cases. The NR1H4 gene has been identified as one of the genes that play a role in the development of ICP. By understanding the symptoms, diagnosis, and treatment options available, women can take steps to manage this condition and ensure a healthy pregnancy. If you suspect you may have ICP, speak with your healthcare provider immediately.

Before getting tested ask for Raw Data, FASTQ, and VCF files along with clinical test report from DNA Testing Lab. DNA Labs India is the Only lab that is transparent and will share Raw Data, FASTQ, and VCF files along with the conclusive clinical report for NR1H4 Gene Intrahepatic cholestasis of pregnancy, NR1H4 related NGS Genetic DNA Test