Short Description

NGS genetic DNA test detecets for variant and mutation detection in MT-TL1 gene for MELAS syndrome, MT-TL1 related

PreTest Information

Clinical History of Patient who is going for MT-TL1 Gene MELAS syndrome, MT-TL1 related NGS Genetic DNA Test A Genetic Counselling session to draw a pedigree chart of family members affected with MT-TL1 Gene MELAS syndrome, MT-TL1 related

Detail Description

MT-TL1 Gene and MELAS Syndrome: Symptoms, Diagnosis and NGS Genetic DNA Test Cost in India

MT-TL1 is a gene that encodes for the mitochondrial tRNA for leucine 1. Mutations in this gene have been linked to mitochondrial disorders, including MELAS (Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like episodes) syndrome. MELAS syndrome is a rare genetic disorder that affects the nervous system and causes various symptoms such as seizures, headaches, muscle weakness, and stroke-like episodes. In this blog, we will discuss the symptoms, diagnosis, and NGS genetic DNA test cost for MT-TL1 related disorders.

Symptoms of MT-TL1 Related Disorders

The symptoms of MT-TL1 related disorders can vary widely depending on the severity of the mutation. However, the most common symptoms of MELAS syndrome are:

• Stroke-like episodes
• Seizures
• Muscle weakness
• Migraines or severe headaches
• Hearing loss
• Difficulty speaking or swallowing
• Heart problems
• Vision problems
• Diabetes

It is important to note that not all individuals with a mutation in the MT-TL1 gene will develop MELAS syndrome. Some individuals may only experience mild symptoms, while others may have more severe symptoms.

Diagnosis of MT-TL1 Related Disorders

Diagnosing MT-TL1 related disorders can be challenging because the symptoms can be similar to other neurological disorders. However, a diagnosis of MELAS syndrome is typically made based on a combination of clinical symptoms, family history, and genetic testing.

A muscle biopsy may be performed to look for characteristic changes in the mitochondria. Additionally, genetic testing can be done to look for mutations in the MT-TL1 gene. Next-generation sequencing (NGS) technology can be used to identify mutations in multiple genes associated with mitochondrial disorders, including MT-TL1.

NGS Genetic DNA Test Cost for MT-TL1 Related Disorders in India

The cost of NGS genetic DNA testing for MT-TL1 related disorders in India can vary depending on the laboratory and the specific test ordered. However, on average, the cost of an NGS genetic DNA test for MT-TL1 related disorders can range from INR 20,000 to INR 30,000.

It is important to note that not all insurance companies cover the cost of genetic testing. However, some insurance companies may cover the cost of genetic testing if it is deemed medically necessary. It is important to check with your insurance provider to determine your coverage.

Conclusion

MELAS syndrome is a rare genetic disorder that can cause a range of symptoms, including stroke-like episodes, seizures, and muscle weakness. Mutations in the MT-TL1 gene have been linked to mitochondrial disorders, including MELAS syndrome. NGS genetic DNA testing can be used to identify mutations in the MT-TL1 gene and other genes associated with mitochondrial disorders. The cost of NGS genetic DNA testing in India can vary, but on average, it ranges from INR 20,000 to INR 30,000. If you or a loved one is experiencing symptoms of MELAS syndrome or other mitochondrial disorders, it is important to seek medical attention and consider genetic testing to determine the underlying cause of the symptoms.

For more information on MT-TL1 gene and MELAS syndrome, please contact DNA Labs India.

Before getting tested ask for Raw Data, FASTQ, and VCF files along with clinical test report from DNA Testing Lab. DNA Labs India is the Only lab that is transparent and will share Raw Data, FASTQ, and VCF files along with the conclusive clinical report for MT-TL1 Gene MELAS syndrome, MT-TL1 related NGS Genetic DNA Test