Short Description

NGS genetic DNA test detecets for variant and mutation detection in MT-ND3 gene for Leigh syndrome due to mitochondrial complex I deficiency

PreTest Information

Clinical History of Patient who is going for MT-ND3 Gene Leigh syndrome due to mitochondrial complex I deficiency NGS Genetic DNA Test A Genetic Counselling session to draw a pedigree chart of family members affected with MT-ND3 Gene Leigh syndrome due to mitochondrial complex I deficiency

Detail Description

MT-ND3 Gene Leigh Syndrome Due to Mitochondrial Complex I Deficiency NGS Genetic DNA Test Cost INR:20000 Symptoms Diagnosis

Leigh syndrome is a rare neurological disorder that usually affects infants and young children. It is a progressive disease that can cause a variety of symptoms, including seizures, developmental delays, and muscle weakness. There are several different genetic mutations that can cause Leigh syndrome, including mutations in the MT-ND3 gene. Mitochondrial complex I deficiency is a condition that occurs when there is a problem with the first complex in the mitochondrial electron transport chain. This can lead to a variety of health problems, including Leigh syndrome.

MT-ND3 Gene and Leigh Syndrome

The MT-ND3 gene is located on the mitochondrial DNA. It encodes a subunit of the mitochondrial complex I enzyme, which is responsible for the first step in the electron transport chain. Mutations in the MT-ND3 gene can cause mitochondrial complex I deficiency, which can lead to Leigh syndrome.

Leigh syndrome is a progressive disease that can cause a variety of symptoms, including:

• Seizures
• Developmental delays
• Muscle weakness
• Difficulty breathing
• Loss of motor control
• Optic atrophy

These symptoms can vary depending on the age of onset, severity of the disease, and the specific genetic mutation causing the disease.

Diagnosis of Leigh Syndrome

Diagnosis of Leigh syndrome can be difficult and may require a combination of tests, including blood tests, imaging studies, and genetic testing. Genetic testing can be particularly useful in identifying the specific genetic mutation causing the disease.

Next-generation sequencing (NGS) is a powerful tool for genetic testing that can identify mutations in multiple genes simultaneously. NGS can be particularly useful for identifying mutations in mitochondrial DNA, which can be difficult to detect using traditional genetic testing methods.

Cost of NGS Genetic DNA Test for MT-ND3 Gene Leigh Syndrome

The cost of NGS genetic DNA testing for Leigh syndrome can vary depending on the specific test and the laboratory performing the test. In India, the cost of NGS genetic DNA testing for MT-ND3 gene Leigh syndrome is typically around INR 20,000.

Conclusion

Leigh syndrome is a rare neurological disorder that can be caused by mutations in the MT-ND3 gene. Mitochondrial complex I deficiency is a condition that can lead to Leigh syndrome. Diagnosis of Leigh syndrome can be difficult and may require a combination of tests, including genetic testing. NGS genetic DNA testing can be particularly useful for identifying mutations in mitochondrial DNA. The cost of NGS genetic DNA testing for MT-ND3 gene Leigh syndrome in India is typically around INR 20,000.

If you suspect that you or a loved one may have Leigh syndrome, it is important to speak with a healthcare provider for proper diagnosis and treatment.

Before getting tested ask for Raw Data, FASTQ, and VCF files along with clinical test report from DNA Testing Lab. DNA Labs India is the Only lab that is transparent and will share Raw Data, FASTQ, and VCF files along with the conclusive clinical report for MT-ND3 Gene Leigh syndrome due to mitochondrial complex I deficiency NGS Genetic DNA Test