Short Description

The Maternal serum screen 2 Advanced is a screen test done between 10-13 weeks of pregnancy. It has significant utility in Prenatal Screening of Down Syndrome Trisomy 21. By reflexing Maternal Dual test with MBFD at chromosome 21, the specificity of the test increases to >99% with a false positive rate of <0.05%.

PreTest Information

Provide maternal Date of birth (dd/mm/yy); LMP or Ultrasound; Number of Fetuses (Single/Twins); Diabetic status and Body Weight in Kg, IVF, Smoking & Previous history of Trisomy 21 pregnancy. All positive results to submit 10 mL whole blood in a Special tube available from LPL for MBFD-21/NIPT along with duly filled Maternal Serum Screen 2 reflex to MBFD-21 consent form (Form 12). Valid between 10-13 weeks gestation.

Detail Description

MATERNAL SERUM SCREEN 2: ADVANCED REFLEX TO MATERNAL BLOOD FOR FETAL DNA (MBFD) CHROMOSOME 21 Test

Maternal serum screening is a test that helps to determine the risk of certain birth defects in a developing fetus. The test is done during pregnancy and measures the levels of certain substances in the mother's blood. One of the most common tests is called the Maternal Serum Screen 2 (MSS2), which includes an advanced reflex to maternal blood for fetal DNA (MBFD) chromosome 21 test. This test is used to screen for Down syndrome and other chromosomal abnormalities.

Symptoms of Down Syndrome

Down syndrome is a genetic condition that affects a person's physical and mental development. Some common symptoms of Down syndrome include:

• Small head and ears
• A flat nose and upward slanting eyes
• A short neck and small mouth
• A broad, short hands with a single crease in the palm
• A short stature and low muscle tone
• An intellectual disability

It's important to note that not all people with Down syndrome will exhibit all of these symptoms. Some may have only a few of these characteristics, while others may have more severe symptoms.

Diagnosis of Down Syndrome

The diagnosis of Down syndrome is typically made after birth, based on physical characteristics and the results of genetic testing. However, the MBFD chromosome 21 test can be done during pregnancy to screen for the condition.

The test is done by taking a sample of the mother's blood and analyzing it for the presence of fetal DNA. If the test comes back positive for an increased risk of Down syndrome, further testing may be recommended to confirm the diagnosis.

Cost of the MBFD Chromosome 21 Test

The cost of the MBFD chromosome 21 test varies depending on the provider and location. In India, the test typically costs around INR 3500.

Conclusion

The Maternal Serum Screen 2 with an advanced reflex to maternal blood for fetal DNA (MBFD) chromosome 21 test is an important tool in screening for Down syndrome and other chromosomal abnormalities during pregnancy. If you're pregnant and want to learn more about this test, talk to your healthcare provider.

At DNA Labs India, we offer a wide range of genetic testing services, including the MBFD chromosome 21 test. Our team of experts is dedicated to providing accurate and reliable results to help you make informed decisions about your health and the health of your baby. Contact us today to learn more.