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LHCGR Gene Precocious puberty, male NGS Genetic DNA Test Details
Precocious Puberty in Males: Understanding LHCGR Gene and NGS Genetic DNA Test
Introduction
Precocious puberty is a condition that affects boys and girls, but it is more common in girls. It refers to the onset of puberty before the age of 8 in girls and 9 in boys. Precocious puberty in males is a rare condition, but it can have serious consequences if left untreated. One of the genes associated with precocious puberty in males is the LHCGR gene. In this blog, we will discuss the LHCGR gene, precocious puberty in males, symptoms, diagnosis, and the NGS Genetic DNA test cost in India.
The LHCGR Gene
The LHCGR gene is located on chromosome 2 and encodes the luteinizing hormone/choriogonadotropin receptor (LHCGR). This receptor is found on the surface of Leydig cells in the testes and plays a critical role in the production of testosterone. Mutations in the LHCGR gene can lead to precocious puberty in males.
Precocious Puberty in Males
Precocious puberty in males is defined as the onset of puberty before the age of 9. It is a rare condition, affecting only 1 in 5,000 to 10,000 boys. The condition is caused by an increase in testosterone production, which leads to the development of secondary sexual characteristics such as pubic hair, facial hair, and deepening of the voice. Precocious puberty in males can have serious consequences such as reduced final height, infertility, and psychological issues.
Symptoms of Precocious Puberty in Males
The symptoms of precocious puberty in males include:
- Growth of pubic and facial hair
- Enlargement of the testicles
- Deepening of the voice
- Acne
- Body odor
- Early growth spurt
Diagnosis of Precocious Puberty in Males
The diagnosis of precocious puberty in males involves a physical exam, blood tests, and imaging tests. Blood tests can measure the levels of testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH). Imaging tests such as MRI can also be used to visualize the pituitary gland and rule out any tumors.
NGS Genetic DNA Test
The NGS Genetic DNA test is a type of genetic test that can identify mutations in the LHCGR gene. This test uses next-generation sequencing technology to analyze the DNA sequence of the gene and detect any mutations. The test can be performed on a blood sample and is a non-invasive procedure. The NGS Genetic DNA test cost in India is approximately INR 20,000.
Conclusion
Precocious puberty in males is a rare condition that can have serious consequences if left untreated. The LHCGR gene is one of the genes associated with precocious puberty in males. Symptoms of the condition include the growth of pubic and facial hair, enlargement of the testicles, and deepening of the voice. Diagnosis involves a physical exam, blood tests, and imaging tests. The NGS Genetic DNA test can be used to identify mutations in the LHCGR gene and is a non-invasive procedure that costs approximately INR 20,000 in India. Early diagnosis and treatment of precocious puberty in males can prevent long-term complications and improve outcomes.
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