Short Description

NGS genetic DNA test detecets for variant and mutation detection in LAMA5 gene for Focal segmental glomerulosclerosis, LAMA5 related

PreTest Information

Clinical History of Patient who is going for LAMA5 Gene Focal segmental glomerulosclerosis, LAMA5 related NGS Genetic DNA Test. A Genetic Counselling session to draw a pedigree chart of family members affected with LAMA5 Gene Focal segmental glomerulosclerosis, LAMA5 related NGS Genetic DNA Test gene LAMA5

Detail Description

LAMA5 Gene Focal Segmental Glomerulosclerosis - DNA Labs India

Focal Segmental Glomerulosclerosis (FSGS) is a rare kidney disease that affects the glomeruli, which are tiny filters in the kidneys that remove waste products from the blood. FSGS is a progressive disease that can lead to kidney failure. The LAMA5 gene is one of the genes that has been identified as being associated with FSGS.

LAMA5 Gene and FSGS

The LAMA5 gene provides instructions for making a protein called laminin alpha-5. This protein is a component of the extracellular matrix, which is the material that surrounds cells in the body. Laminin alpha-5 is found in the glomeruli of the kidneys, where it helps to maintain the structure and function of these tiny filters. Mutations in the LAMA5 gene can lead to a reduction in the amount or activity of laminin alpha-5, which can contribute to the development of FSGS.

Symptoms of FSGS

FSGS can cause a range of symptoms, including:

• Proteinuria (excess protein in the urine)
• Edema (swelling) in the legs, feet, or ankles
• High blood pressure
• Reduced kidney function
• Fatigue
• Nausea
• Loss of appetite

Diagnosis of FSGS

FSGS is typically diagnosed through a combination of physical examination, blood tests, urine tests, and kidney biopsy. Genetic testing can also be used to identify mutations in genes like LAMA5 that may be contributing to the disease.

LAMA5 Related NGS Genetic DNA Test

DNA Labs India offers a LAMA5-related NGS genetic DNA test that can help to identify mutations in the LAMA5 gene. This test uses next-generation sequencing (NGS) technology to analyze the entire LAMA5 gene and identify any mutations that may be present. The cost of this test is INR 20,000.

Conclusion

FSGS is a rare kidney disease that can have serious consequences if left untreated. Mutations in the LAMA5 gene have been identified as a potential cause of FSGS. DNA Labs India offers a LAMA5-related NGS genetic DNA test that can help to identify mutations in this gene. If you are experiencing symptoms of FSGS or have a family history of the disease, we encourage you to speak with your healthcare provider about the possibility of genetic testing.

Before getting tested ask for Raw Data, FASTQ, and VCF files along with clinical test report from DNA Testing Lab. DNA Labs India is the Only lab that is transparent and will share Raw Data, FASTQ, and VCF files along with the conclusive clinical report for LAMA5 Gene Focal segmental glomerulosclerosis, LAMA5 related NGS Genetic DNA Test