Short Description

RAS mutations are commonly found in cancer tissue, causing a permanent activation of the signal transduction pathway downstream of the EGF receptor (EGFR), thus positive signaling for cell growth. Most frequent are KRAS mutations in codons 12,13 in the second (first transcribed) exon. Up to 45% of all colorectal cancer patients exhibit KRAS 12,13 mutations, while another 10-15% may have mutations in KRAS exons 3 and 4 or in the respective regions of the homologous NRAS gene.

PreTest Information

Duly filled NGS Test Requisition Form (Form 40) is mandatory.

Detail Description

Understanding KRAS & NRAS Mutation Analysis Panel Test and Its Cost in India

When it comes to cancer diagnosis and treatment, genetic testing plays a crucial role. KRAS and NRAS are two genes that have been found to be associated with various types of cancer. Mutations in these genes can affect the efficacy of certain cancer treatments. This is where KRAS & NRAS mutation analysis panel test comes into the picture. In this blog, we will discuss what this test is, its cost in India, and how it can help in diagnosis.

What is KRAS & NRAS Mutation Analysis Panel Test?

KRAS & NRAS mutation analysis panel test is a genetic test that checks for mutations in the KRAS and NRAS genes. These genes are responsible for producing proteins that help regulate cell growth and division. Mutations in these genes can lead to the development of various types of cancer, including colorectal cancer, lung cancer, and pancreatic cancer.

The test is usually done on a sample of blood or tissue. The sample is sent to a laboratory where it is analyzed to detect any mutations in the KRAS and NRAS genes. The results of the test can help doctors determine the best treatment plan for the patient.

What are the Symptoms of KRAS & NRAS Mutations?

There are no specific symptoms associated with KRAS and NRAS mutations. However, these mutations have been found to be associated with certain types of cancer. The symptoms of cancer can vary depending on the type of cancer and the stage of the disease. Some common symptoms of cancer include:

• Unexplained weight loss
• Fatigue
• Persistent cough
• Changes in bowel or bladder habits
• Difficulty swallowing
• Bleeding or discharge from any body orifice

How is KRAS & NRAS Mutation Analysis Panel Test Diagnosed?

KRAS & NRAS mutation analysis panel test is usually done after a person has been diagnosed with cancer. The test can help determine whether the cancer is likely to respond to certain treatments. The test is usually done on a sample of blood or tissue taken during a biopsy or surgery.

What is the Cost of KRAS & NRAS Mutation Analysis Panel Test in India?

The cost of KRAS & NRAS mutation analysis panel test in India varies depending on the laboratory and location. On average, the cost of the test ranges from INR 15,000 to INR 20,000. However, the cost may be higher or lower depending on various factors such as the type of cancer being tested for and the location of the laboratory.

Conclusion

KRAS & NRAS mutation analysis panel test is a crucial genetic test that can help in the diagnosis and treatment of certain types of cancer. The test can detect mutations in the KRAS and NRAS genes, which can affect the efficacy of certain cancer treatments. The cost of the test in India varies depending on various factors such as the type of cancer being tested for and the location of the laboratory.

If you have been diagnosed with cancer, it is important to discuss the possibility of KRAS & NRAS mutation analysis panel test with your doctor. The test can help determine the best treatment plan for you.

RAS mutations are commonly found in cancer tissue, causing a permanent activation of the signal transduction pathway downstream of the EGF receptor (EGFR), thus positive signaling for cell growth. Most frequent are KRAS mutations in codons 12,13 in the second (first transcribed) exon. Up to 45% of all colorectal cancer patients exhibit KRAS 12,13 mutations, while another 10-15% may have mutations in KRAS exons 3 and 4 or in the respective regions of the homologous NRAS gene.