Short Description

Irnotecan Toxicity Assessment (UGT1A1 Genotyping)/ Gilbert Syndrome is performed using Sanger Sequencing methodology. Sample that have to be given is Peripheral Blood in EDTA Vacutainer (2ml) for this test. You can expect results in 7-8 days

PreTest Information

Irnotecan Toxicity Assessment (UGT1A1 Genotyping)/ Gilbert Syndrome can be done with a Doctor’s prescription. Prescription is not applicable for surgery and pregnancy cases or people planing to travel abroad.

Detail Description

Irnotecan Toxicity Assessment (UGT1A1 Genotyping)/ Gilbert Syndrome

Irnotecan is a chemotherapy drug used in the treatment of various types of cancer such as colorectal cancer, lung cancer, and pancreatic cancer. However, it can cause toxicity in some individuals, which can lead to severe side effects. This toxicity is related to the UGT1A1 gene, which is responsible for metabolizing irnotecan. Individuals with Gilbert Syndrome are at higher risk of irnotecan toxicity due to a decreased ability to metabolize the drug.

Symptoms of Irnotecan Toxicity

The symptoms of irnotecan toxicity can include:

• Nausea and vomiting
• Diarrhea
• Fever and chills
• Decreased white blood cell count
• Decreased platelet count
• Increased liver enzymes
• Jaundice

Diagnosis

The diagnosis of irnotecan toxicity is typically made based on symptoms and blood tests. However, it can be challenging to differentiate irnotecan toxicity from other side effects of chemotherapy. Therefore, it is important to perform UGT1A1 genotyping to determine the risk of toxicity in individuals receiving irnotecan.

Gilbert Syndrome

Gilbert Syndrome is a genetic disorder that affects the liver's ability to process bilirubin, a substance produced when red blood cells break down. This leads to a buildup of bilirubin in the blood, causing jaundice. Individuals with Gilbert Syndrome are at higher risk of irnotecan toxicity due to a decreased ability to metabolize the drug.

Irnotecan Toxicity Assessment (UGT1A1 Genotyping)

UGT1A1 genotyping is a simple blood test that determines an individual's risk of irnotecan toxicity. It identifies variations in the UGT1A1 gene that affect the metabolism of irnotecan. Individuals with certain variations are at higher risk of irnotecan toxicity and may require a lower dose of the drug or an alternative chemotherapy treatment.

Cost of Irnotecan Toxicity Assessment (UGT1A1 Genotyping)/ Gilbert Syndrome

The cost of UGT1A1 genotyping for irnotecan toxicity assessment or Gilbert Syndrome in India is typically around INR 7500. However, the cost may vary depending on the location and laboratory performing the test.

Conclusion

Irnotecan toxicity can cause severe side effects in some individuals receiving chemotherapy. UGT1A1 genotyping is a simple blood test that can identify individuals at higher risk of toxicity and help determine the appropriate dose or alternative treatment. Individuals with Gilbert Syndrome are at higher risk of irnotecan toxicity and should consider UGT1A1 genotyping before receiving the drug. The cost of UGT1A1 genotyping for irnotecan toxicity assessment or Gilbert Syndrome in India is typically around INR 7500.

It is important to consult with a healthcare provider for proper diagnosis and treatment of irnotecan toxicity or Gilbert Syndrome.

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