Short Description

MUM1 (Multiple myeloma oncogene 1) is expressed in late plasma cell directed stages of B cell differentiation and in activated T cells, suggesting that MUM1 may serve as a marker for lympho-hemopoietic neoplasms derived from these cells. The expression of MUM1 is seen in Plasma cell myeloma & Extraosseous plasmacytomas. Among non-hematolymphoid neoplasms, MUM-1 expression has been reported in Melanomas.

PreTest Information

Provide a copy of the Histopathology report, Site of biopsy and Clinical history.

Detail Description

IMMUNOHISTOCHEMISTRY MUM1 Test Cost INR:3500 Symptoms Diagnosis

Immunohistochemistry is a diagnostic test that uses antibodies to detect specific proteins in tissues and cells. It is a valuable tool for diagnosing and treating cancer, as it can help determine the type of cancer and the best treatment options. One such test is the Immunohistochemistry MUM1 test, which is used to detect the MUM1 protein in tissues.

What is the MUM1 Protein?

The MUM1 protein is a transcriptional regulator that plays a role in the differentiation and function of B-cells. It is also known as IRF4 (Interferon Regulatory Factor 4) and is involved in regulating the immune response. The MUM1 protein is expressed in a variety of B-cell malignancies, including multiple myeloma, diffuse large B-cell lymphoma, and Burkitt lymphoma.

Why is the Immunohistochemistry MUM1 Test Done?

The Immunohistochemistry MUM1 test is done to help diagnose and classify B-cell malignancies. The test is particularly useful in distinguishing between different types of diffuse large B-cell lymphoma. It is also used to monitor the effectiveness of treatment and to detect any recurrence of the cancer.

How is the Test Done?

The Immunohistochemistry MUM1 test is done on a tissue sample taken from the patient. The tissue sample is processed and stained with antibodies that specifically bind to the MUM1 protein. The stained tissue is then examined under a microscope to determine the presence and distribution of the MUM1 protein.

What are the Symptoms of B-cell Malignancies?

The symptoms of B-cell malignancies can vary depending on the type and stage of the cancer. Some common symptoms include:

• Enlarged lymph nodes
• Fever
• Night sweats
• Fatigue
• Unexplained weight loss
• Loss of appetite
• Bone pain
• Abdominal swelling
• Shortness of breath

How is B-cell Malignancy Diagnosed?

B-cell malignancies are diagnosed through a combination of tests, including:

• Physical exam
• Blood tests
• Imaging tests (such as X-rays, CT scans, or MRIs)
• Tissue biopsy
• Immunohistochemistry tests

How much does the Immunohistochemistry MUM1 test cost?

The cost of the Immunohistochemistry MUM1 test in India can vary depending on the lab and location. At DNA Labs India, the cost of the test is INR 3500.

Conclusion

The Immunohistochemistry MUM1 test is an important diagnostic tool for detecting and classifying B-cell malignancies. It is particularly useful in distinguishing between different types of diffuse large B-cell lymphoma. If you are experiencing any symptoms of B-cell malignancy, it is important to see a doctor for diagnosis and treatment.

MUM1 (Multiple myeloma oncogene 1) is expressed in late plasma cell directed stages of B cell differentiation and in activated T cells, suggesting that MUM1 may serve as a marker for lympho-hemopoietic neoplasms derived from these cells. The expression of MUM1 is seen in Plasma cell myeloma & Extraosseous plasmacytomas. Among non-hematolymphoid neoplasms, MUM-1 expression has been reported in Melanomas.