Short Description

Isocitrate Dehydrogenase (IDH-1) mutations have been implicated in Diffuse Astrocytomas, Oligodendrogliomas and Glioblastomas and is essential for typing and classification of gliomas according to current WHO 2016 guidelines.

PreTest Information

Provide a copy of the Histopathology report, Site of biopsy and Clinical history.

Detail Description

IMMUNOHISTOCHEMISTRY ISOCITRATE DEHYDROGENASE (IDH-1) Test: Cost, Symptoms, and Diagnosis

Immunohistochemistry Isocitrate Dehydrogenase (IDH-1) Test is a diagnostic test that helps in identifying the presence of IDH-1 mutation in various tumors. The test helps in the diagnosis of gliomas, a type of brain tumors. The test is considered to be highly effective and reliable in detecting the IDH-1 mutation.

What is IDH-1 Mutation?

The IDH-1 mutation is a genetic alteration that is commonly found in various types of tumors, including gliomas. The mutation is caused by the alteration in the IDH-1 gene that results in the production of a faulty IDH-1 enzyme. The mutated enzyme produces a metabolite that is toxic to the cells and can lead to the development of tumors.

Symptoms of IDH-1 Mutation

The symptoms of IDH-1 mutation vary depending on the type and location of the tumor. However, some common symptoms include:

• Headaches
• Nausea and vomiting
• Seizures
• Weakness or numbness in the arms or legs
• Difficulty speaking or understanding language

Diagnosis of IDH-1 Mutation

The Immunohistochemistry Isocitrate Dehydrogenase (IDH-1) Test is used to diagnose the IDH-1 mutation. The test involves taking a tissue sample from the affected area and examining it under a microscope. The tissue sample is then stained with a special dye that helps in identifying the presence of the mutated IDH-1 enzyme. The test is highly sensitive and specific in detecting the mutation, making it a reliable diagnostic tool.

Cost of IDH-1 Mutation Test

The cost of the Immunohistochemistry Isocitrate Dehydrogenase (IDH-1) Test in India is around INR 3500. However, the cost may vary depending on the location and the laboratory where the test is conducted. It is always recommended to check with the laboratory or healthcare provider to get an accurate estimate of the cost.

Conclusion

The Immunohistochemistry Isocitrate Dehydrogenase (IDH-1) Test is a reliable and effective diagnostic tool for identifying the presence of IDH-1 mutation in various tumors, including gliomas. The test is highly sensitive and specific, making it a valuable tool in the diagnosis and treatment of tumors. If you experience any of the symptoms associated with IDH-1 mutation, it is recommended to consult with a healthcare provider and get the necessary tests done.

For more information on diagnostic tests and healthcare services, please visit DNA Labs India.

Isocitrate Dehydrogenase (IDH-1) mutations have been implicated in Diffuse Astrocytomas, Oligodendrogliomas and Glioblastomas and is essential for typing and classification of gliomas according to current WHO 2016 guidelines.