Short Description

E-Cadherin (ECAD) is typically associated with epithelial differentiation. It is immunoreactive in epithelial neoplasms as well as mesenchymal tumors with epithelial characteristics like Synovial sarcoma. Strong E-cadherin membranous staining is used to define Ductal carcinomas of breast & differentiate from Lobular carcinomas which are negative. Loss of cell surface E-Cadherin expression is also seen in Solid pseudopapillary neoplasms of the pancreas.

PreTest Information

Provide a copy of the Histopathology report, Site of biopsy and Clinical history.

Detail Description

IMMUNOHISTOCHEMISTRY E-CADHERIN (ECAD) Test: Symptoms, Diagnosis, and Cost

Immunohistochemistry (IHC) is a diagnostic tool that helps in the identification of specific proteins in tissues. It is commonly used in the detection of cancerous cells and their characterization. E-cadherin (ECAD) is a protein that plays an essential role in the adhesion of cells, and its loss is associated with the development and progression of cancer. The ECAD test is used to determine the presence of ECAD in tissues and its level of expression.

Symptoms

The ECAD test is commonly used in the diagnosis of cancer. The loss of ECAD is associated with the development and progression of various types of cancer, including breast, gastric, colorectal, and pancreatic cancers. The symptoms of these cancers vary depending on the type and stage of cancer. Some common symptoms include:

• Unexplained weight loss
• Fatigue
• Persistent cough
• Difficulty swallowing
• Bloating or abdominal pain
• Changes in bowel or bladder habits
• Unusual bleeding or discharge

If you experience any of these symptoms, it is essential to consult a doctor for further evaluation and diagnosis.

Diagnosis

The ECAD test is performed on tissue samples obtained from a biopsy or surgery. The tissue sample is fixed in formalin and embedded in paraffin wax. Thin sections of the tissue are cut and placed on glass slides. The slides are then stained with antibodies that specifically bind to ECAD. The presence and level of ECAD expression are determined by examining the stained slides under a microscope.

The ECAD test is commonly used in the diagnosis of cancer. It helps in the identification and characterization of cancer cells and their behavior. The loss of ECAD is associated with the development and progression of cancer and can help in determining the prognosis of the disease.

Cost

The cost of the ECAD test in India varies depending on the laboratory and location. On average, the cost of the ECAD test in India is around INR 3000. However, the cost may vary depending on the laboratory, location, and other factors.

It is essential to consult a doctor before undergoing the ECAD test. The doctor can recommend the appropriate laboratory for the test and provide guidance on the cost and other factors.

Conclusion

The ECAD test is an essential diagnostic tool in the diagnosis of cancer. The loss of ECAD is associated with the development and progression of cancer, and the ECAD test can help in determining the prognosis of the disease. If you experience any symptoms of cancer, it is essential to consult a doctor for further evaluation and diagnosis. The cost of the ECAD test may vary depending on the laboratory and location, and it is essential to consult a doctor for guidance on the appropriate laboratory and cost.

E-Cadherin (ECAD) is typically associated with epithelial differentiation. It is immunoreactive in epithelial neoplasms as well as mesenchymal tumors with epithelial characteristics like Synovial sarcoma. Strong E-cadherin membranous staining is used to define Ductal carcinomas of breast & differentiate from Lobular carcinomas which are negative. Loss of cell surface E-Cadherin expression is also seen in Solid pseudopapillary neoplasms of the pancreas.