Short Description

Caldesmon is a smooth muscle and non-muscle regulatory protein that interacts with actin, myosin, tropomyosin, and calmodulin. Smooth muscle caldesmon is an elongated molecule with a calmodulin, tropomyosin, and action-binding region at the C-terminus and a myosin binding domain at the N-terminus. Caldesmon stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, caldesmon inhibits the actomyosin ATPase by binding to F-Actin. Caldesmon is a useful marker for smooth muscle tumors.

PreTest Information

Provide a copy of the Histopathology report, Site of biopsy and Clinical history.

Detail Description

IMMUNOHISTOCHEMISTRY CALDESMON Test: Cost, Symptoms, and Diagnosis

IMMUNOHISTOCHEMISTRY CALDESMON is a diagnostic test that is used to determine the presence of caldesmon in tissues. Caldesmon is a protein that is found in smooth muscle cells, and its presence is an indicator of smooth muscle differentiation. The test is used to diagnose a variety of conditions, including tumors, fibromatosis, and leiomyomas.

Symptoms

The symptoms associated with the conditions that the IMMUNOHISTOCHEMISTRY CALDESMON test is used to diagnose can vary depending on the specific condition. However, some common symptoms include:

• Abdominal pain
• Abnormal uterine bleeding
• Bloating
• Constipation
• Diarrhea
• Pain during intercourse
• Rectal bleeding
• Urinary frequency or urgency

Diagnosis

The IMMUNOHISTOCHEMISTRY CALDESMON test is used to diagnose a variety of conditions, including:

• Gastrointestinal stromal tumors (GISTs)
• Leiomyomas
• Leiomyosarcomas
• Low-grade fibromatosis
• Smooth muscle tumors of uncertain malignant potential (STUMP)
• Uterine leiomyosarcomas

The IMMUNOHISTOCHEMISTRY CALDESMON test is performed on tissue samples that have been obtained through a biopsy or surgery. The tissue sample is stained with antibodies that bind to caldesmon, allowing its presence to be detected.

Cost

The cost of the IMMUNOHISTOCHEMISTRY CALDESMON test in India is typically around INR 3500. However, the cost can vary depending on the location and the laboratory that performs the test.

Conclusion

The IMMUNOHISTOCHEMISTRY CALDESMON test is a valuable diagnostic tool that can be used to detect the presence of caldesmon in tissues. By identifying the presence of caldesmon, healthcare professionals can better diagnose and treat a variety of conditions, including tumors, fibromatosis, and leiomyomas. If you are experiencing symptoms that may be related to these conditions, talk to your healthcare provider about whether the IMMUNOHISTOCHEMISTRY CALDESMON test may be right for you.

For more information on the IMMUNOHISTOCHEMISTRY CALDESMON test or to schedule an appointment, contact DNA Labs India today. Our team of experienced professionals is dedicated to providing high-quality, affordable diagnostic testing services to patients throughout India.

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Caldesmon is a smooth muscle and non-muscle regulatory protein that interacts with actin, myosin, tropomyosin, and calmodulin. Smooth muscle caldesmon is an elongated molecule with a calmodulin, tropomyosin, and action-binding region at the C-terminus and a myosin binding domain at the N-terminus. Caldesmon stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, caldesmon inhibits the actomyosin ATPase by binding to F-Actin. Caldesmon is a useful marker for smooth muscle tumors.