Short Description

Potential marker for prediction of IDH/H3F3A mutations and substratification of Diffuse gliomas / Primary glioblastomas into survival relevant tumor groups. Such classification is of great importance for further clinical decision making specially concerning the therapeutic options available for Diffuse gliomas. ATRX alterations are frequent and are associated with Astrocytic tumors carrying additional IDH1/2 and TP53 mutations. Missense and truncating mutations of ATRX gene lead to loss of expression in Gliomas and correlates with better clinical outcome in a subset of IDH1 mutant tumors.

PreTest Information

Provide a copy of the Histopathology report, Site of biopsy and Clinical history.

Detail Description

IMMUNOHISTOCHEMISTRY ATRX Test: Understanding the Cost, Symptoms, and Diagnosis

ATRX is a protein that is essential for the proper functioning of the human body. It plays a crucial role in regulating gene expression, DNA replication, and chromatin remodeling. Mutations in the ATRX gene can lead to a rare genetic disorder called ATR-X syndrome, which is characterized by intellectual disability, developmental delays, and other physical abnormalities.

Immunohistochemistry (IHC) ATRX test is a diagnostic test that helps detect mutations in the ATRX gene. The test uses antibodies to identify the presence of ATRX protein in tissue samples. The IHC ATRX test is a highly sensitive and specific diagnostic tool that can help physicians diagnose ATR-X syndrome and other ATRX-related disorders.

Symptoms of ATR-X Syndrome

The symptoms of ATR-X syndrome can vary depending on the severity of the condition. Some common symptoms include:

• Intellectual disability
• Developmental delays
• Abnormal facial features
• Genital abnormalities
• Seizures
• Skeletal abnormalities
• Behavioral problems
• Speech and language delays

Diagnosis of ATR-X Syndrome

Diagnosing ATR-X syndrome can be challenging as the symptoms can vary widely. Physicians may use a combination of clinical evaluation, genetic testing, and imaging studies to diagnose the condition. The IHC ATRX test is a highly specific diagnostic tool that can help confirm a diagnosis of ATR-X syndrome.

Cost of IHC ATRX Test in India

The cost of the IHC ATRX test in India can vary depending on the healthcare facility and location. On average, the cost of the test ranges from INR 3500 to INR 5000. It is essential to consult with your healthcare provider or insurance provider to determine the cost of the test and the coverage available.

Conclusion

The IHC ATRX test is a highly sensitive and specific diagnostic tool that can help diagnose ATR-X syndrome and other ATRX-related disorders. The test is relatively affordable and can provide valuable information to physicians and patients alike. If you suspect that you or a loved one may have ATR-X syndrome, it is essential to seek medical attention and discuss the possibility of an IHC ATRX test with your healthcare provider.

If you are looking for a reliable healthcare facility in India that offers the IHC ATRX test, DNA Labs India is your go-to destination. We have state-of-the-art facilities and a team of experienced healthcare professionals who can provide accurate and reliable diagnosis and treatment. Contact us today to schedule an appointment.

Potential marker for prediction of IDH/H3F3A mutations and substratification of Diffuse gliomas / Primary glioblastomas into survival relevant tumor groups. Such classification is of great importance for further clinical decision making specially concerning the therapeutic options available for Diffuse gliomas. ATRX alterations are frequent and are associated with Astrocytic tumors carrying additional IDH1/2 and TP53 mutations. Missense and truncating mutations of ATRX gene lead to loss of expression in Gliomas and correlates with better clinical outcome in a subset of IDH1 mutant tumors.