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IFNGR1 Gene Mycobacterial infection, atypical, familial disseminated NGS Genetic DNA Test Cost 20000 Rs
IFNGR1 Gene Mycobacterial infection, atypical, familial disseminated NGS Genetic DNA Test Details
IFNGR1 Gene Mycobacterial Infection: Symptoms, Diagnosis and NGS Genetic DNA Test Cost
Mycobacterial infections are caused by bacteria belonging to the genus Mycobacterium. These bacteria can cause a variety of diseases in humans, ranging from tuberculosis and leprosy to atypical mycobacterial infections. One of the genes that play a crucial role in the immune response against mycobacterial infections is the IFNGR1 gene.
What is the IFNGR1 Gene?
The IFNGR1 gene encodes for a protein called the interferon-gamma receptor 1. This receptor is found on the surface of certain immune cells, such as T cells and natural killer cells. When interferon-gamma (a cytokine produced by these cells) binds to the IFNGR1 receptor, it triggers a cascade of events that activate the immune system to fight off infections, including mycobacterial infections.
What is an Atypical Mycobacterial Infection?
Atypical mycobacterial infections are caused by non-tuberculous mycobacteria (NTM) that are found in the environment, such as water and soil. Unlike tuberculosis, atypical mycobacterial infections are not contagious and do not usually spread from person to person.
Atypical mycobacterial infections can affect different parts of the body, such as the lungs, skin, lymph nodes, and bones. The symptoms of these infections can vary depending on the affected area, but they often include fever, cough, fatigue, weight loss, and skin lesions.
Familial Disseminated Atypical Mycobacterial Infections
In rare cases, atypical mycobacterial infections can be inherited in an autosomal recessive manner, meaning that both parents need to carry a mutated gene for their child to be affected. These familial cases are often characterized by disseminated infections, which means that the bacteria can spread to different parts of the body, causing severe and recurrent infections.
Diagnosis of IFNGR1 Gene Mycobacterial Infections
Diagnosing IFNGR1 gene mycobacterial infections can be challenging, as the symptoms can be similar to other respiratory or skin infections. However, a genetic test can identify mutations in the IFNGR1 gene that can lead to a predisposition to mycobacterial infections.
Next-generation sequencing (NGS) is a type of genetic test that can analyze multiple genes simultaneously, including the IFNGR1 gene. NGS can detect both known and novel mutations in the gene, providing a comprehensive evaluation of the patient's genetic predisposition to mycobacterial infections.
NGS Genetic DNA Test Cost
The cost of an NGS genetic DNA test for IFNGR1 gene mycobacterial infections in India can vary depending on the laboratory and the extent of the analysis. However, the average cost of such a test is around INR 20,000.
Conclusion
The IFNGR1 gene plays a crucial role in the immune response against mycobacterial infections, and mutations in this gene can lead to a predisposition to atypical mycobacterial infections, especially in familial cases. Diagnosing these infections can be challenging, but an NGS genetic DNA test can provide a comprehensive evaluation of the patient's genetic predisposition to mycobacterial infections. The cost of such a test is around INR 20,000, making it a valuable investment for patients with suspected IFNGR1 gene mycobacterial infections.
For more information on IFNGR1 gene mycobacterial infections and NGS genetic DNA testing, contact DNA Labs India.
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