Short Description

NGS genetic DNA test detecets for variant and mutation detection in HTRA2 gene for PARK13 Parkinson

PreTest Information

Clinical History of Patient who is going for HTRA2 Gene PARK13 Parkinson NGS Genetic DNA Test A Genetic Counselling session to draw a pedigree chart of family members affected with HTRA2 Gene PARK13 Parkinson

Detail Description

HTRA2 Gene PARK13 Parkinson NGS Genetic DNA Test: Cost, Symptoms, Diagnosis

Parkinson's disease is a neurodegenerative disorder that affects millions of people worldwide. It is a chronic and progressive disorder that affects movement and causes tremors, stiffness, and difficulty in balance and coordination. While the exact cause of Parkinson's disease is still unknown, recent research has identified a potential genetic link. One of the genes that have been found to be linked to Parkinson's disease is the HTRA2 gene, also known as PARK13.

What is the HTRA2 Gene?

The HTRA2 gene is responsible for producing a protein known as high-temperature requirement protein A2. This protein plays a crucial role in the mitochondria, which are the powerhouses of the cells. The protein is involved in the regulation of the mitochondria's function and helps in maintaining their structural integrity. When the HTRA2 gene is mutated, it can lead to a decrease in the protein's production, which can result in mitochondrial dysfunction. Mitochondrial dysfunction has been linked to several neurodegenerative disorders, including Parkinson's disease.

How is the HTRA2 Gene Linked to Parkinson's Disease?

Research has found that mutations in the HTRA2 gene are associated with an increased risk of developing Parkinson's disease. This gene's mutations can cause a decrease in the production of the high-temperature requirement protein A2, which can lead to mitochondrial dysfunction. Mitochondrial dysfunction has been linked to the death of dopamine-producing neurons, which are essential for the regulation of movement. The death of these neurons can result in the development of Parkinson's disease symptoms.

NGS Genetic DNA Test for HTRA2 Gene PARK13 Parkinson

The NGS Genetic DNA test for the HTRA2 gene PARK13 Parkinson is a genetic test that can determine if an individual has a mutation in the HTRA2 gene. This test uses next-generation sequencing (NGS) technology to analyze an individual's DNA for mutations in the HTRA2 gene. The test is highly accurate and can detect even minor mutations in the gene.

Cost of the NGS Genetic DNA Test for HTRA2 Gene PARK13 Parkinson

The cost of the NGS Genetic DNA test for the HTRA2 gene PARK13 Parkinson in India is approximately INR 20,000. The cost may vary depending on the testing facility and the location.

Symptoms of Parkinson's Disease

The symptoms of Parkinson's disease can vary from person to person and may include:

• Tremors or shaking
• Stiffness in the limbs and torso
• Difficulty in balance and coordination
• Slow movement or bradykinesia
• Difficulty in initiating movement or akinesia
• Impaired posture and balance

Diagnosis of Parkinson's Disease

Diagnosing Parkinson's disease can be challenging as there is no definitive test for the disease. The diagnosis is usually made based on the individual's medical history, physical examination, and the presence of Parkinson's disease symptoms. In some cases, a doctor may order imaging tests or blood tests to rule out other conditions that may be causing the symptoms. Genetic testing may also be recommended for individuals with a family history of Parkinson's disease or those with early-onset Parkinson's disease.

Conclusion

The NGS Genetic DNA test for the HTRA2 gene PARK13 Parkinson can help identify individuals at risk of developing Parkinson's disease. Early diagnosis and treatment can help manage the symptoms of Parkinson's disease and improve the individual's quality of life. If you are experiencing Parkinson's disease symptoms or have a family history of the disease, talk to your doctor about the NGS Genetic DNA test for the HTRA2 gene PARK13 Parkinson.