Renal cell carcinoma (RCC) is a type of kidney cancer that arises from the lining of the renal tubules. It accounts for approximately 3% of all adult cancers. There are several subtypes of RCC, and one of them is HNF1A gene-related RCC. This subtype is caused by a germline mutation in the HNF1A gene, which is responsible for encoding a transcription factor that regulates the expression of several genes.

Symptoms

Early stages of HNF1A gene-related RCC may not present any symptoms. However, as the cancer progresses, the following symptoms may occur:

• Blood in urine
• Abdominal pain
• Loss of appetite and weight loss
• Fever
• Fatigue

Diagnosis

Diagnosis of HNF1A gene-related RCC can be done through genetic testing. Next-Generation Sequencing (NGS) genetic DNA testing is an advanced technology that can analyze multiple genes at once. This test can identify the presence of a germline mutation in the HNF1A gene, which can confirm a diagnosis of HNF1A gene-related RCC.

Cost

The cost of NGS genetic DNA testing for HNF1A gene-related RCC at DNA Labs India starts at INR 20,000. This cost may vary depending on the specific requirements of the patient.

Conclusion

HNF1A gene-related RCC is a rare subtype of kidney cancer that is caused by a germline mutation in the HNF1A gene. Early diagnosis of this condition is crucial for effective treatment and management. NGS genetic DNA testing is an advanced technology that can help diagnose this condition and DNA Labs India offers this testing at an affordable cost.