Short Description

Narcolepsy is a multigenic environmentally influenced neurologic sleep disorder affecting 0.01 to 0.15% of the population. Among other genetic regions, it is associated with the HLA class II region of the HLA complex. HLA-DQ6 and/or HLA-DR15 confer susceptibility to Narcolepsy, with variable relative risk according to ethnicity.

PreTest Information

No special preparation required

Detail Description

HLA - NARCOLEPSY (DRB1*15 DQB1*06:02 DQA1*01:02) Test: Symptoms, Diagnosis, and Cost

Narcolepsy is a neurological disorder that affects the ability to regulate sleep-wake cycles. It is characterized by excessive daytime sleepiness, sudden loss of muscle tone (cataplexy), hallucinations, and sleep paralysis. Narcolepsy usually begins in adolescence or early adulthood and can have a significant impact on a person's quality of life.

HLA - Narcolepsy Test

The HLA - narcolepsy test is a genetic test that helps diagnose narcolepsy. It looks for specific variations in the human leukocyte antigen (HLA) genes that are associated with narcolepsy. The test analyzes three genes: DRB1*15, DQB1*06:02, and DQA1*01:02. These genes are found on chromosome 6 and are involved in the body's immune response.

Symptoms of Narcolepsy

The symptoms of narcolepsy can vary from person to person, but the most common symptoms include:

• Excessive daytime sleepiness
• Cataplexy (sudden loss of muscle tone)
• Hallucinations
• Sleep paralysis
• Disrupted nighttime sleep
• Automatic behavior (performing routine tasks without conscious awareness)

These symptoms can significantly impact a person's daily life, making it difficult to perform daily tasks, maintain relationships, and hold down a job.

Diagnosing Narcolepsy

Diagnosing narcolepsy can be challenging because the symptoms are similar to other sleep disorders. A sleep specialist will typically perform a physical exam and ask about the patient's symptoms, medical history, and sleep habits. They may also order a sleep study, which involves monitoring the patient's brain waves, heart rate, breathing, and muscle activity while they sleep.

The HLA - narcolepsy test can also be used to help diagnose narcolepsy. If the test comes back positive for the DRB1*15, DQB1*06:02, and DQA1*01:02 genes, it is an indication that the person may be at a higher risk for developing narcolepsy.

Cost of HLA - Narcolepsy Test

The cost of the HLA - narcolepsy test in India is typically around INR 8500. However, the cost may vary depending on the laboratory and location.

Conclusion

Narcolepsy is a challenging disorder that can significantly impact a person's daily life. The HLA - narcolepsy test is a useful tool for diagnosing narcolepsy and can help patients get the treatment they need to manage their symptoms. If you're experiencing symptoms of narcolepsy, talk to your doctor about whether the HLA - narcolepsy test is right for you.

At DNA Labs India, we offer a wide range of genetic tests, including the HLA - narcolepsy test. Our team of experts is committed to providing accurate and reliable results to help our patients make informed decisions about their health. Contact us today to learn more about our genetic testing services.

Narcolepsy is a multigenic environmentally influenced neurologic sleep disorder affecting 0.01 to 0.15% of the population. Among other genetic regions, it is associated with the HLA class II region of the HLA complex. HLA-DQ6 and/or HLA-DR15 confer susceptibility to Narcolepsy, with variable relative risk according to ethnicity.