Short Description

Presence of HLA B*58:01 is associated with hypersensitivity to Allopurinol therapy. Allopurinol is widely used for hyperuricemia related diseases such as Gout, Lesch- Nyhan Syndrome and recurrent urate kidney stones. Such individuals are at risk of developing Allopurinol hypersensitivity syndrome which includes Toxic Epidermal Necrolysis (TEN) or Stevens- Johnson Syndrome (SJS) and also features of eosinophilia, vasculitis and major end organ disease. Patients of Han Chinese or Thai descent are at a very high risk for developing Allopurinol hypersensitivity syndrome. Therapy should be discontinued immediately and permanently if Allopurinol hypersensitivity syndrome develops.

PreTest Information

No special preparation required

Detail Description

HLA Hypersensitivity to Allopurinol (B*58:01) Test: Symptoms, Diagnosis, and Cost

Allopurinol is a medication used to treat gout and kidney stones. However, some people are hypersensitive to it, which can lead to severe skin reactions and even life-threatening conditions. This hypersensitivity is caused by a genetic variant called HLA-B*58:01. DNA Labs India offers a test to detect this variant, allowing doctors to prescribe allopurinol safely. In this blog, we will discuss the symptoms, diagnosis, and cost of the HLA hypersensitivity to allopurinol (B*58:01) test.

Symptoms of HLA Hypersensitivity to Allopurinol

HLA hypersensitivity to allopurinol can cause a range of symptoms, including:

• Severe skin reactions, such as Stevens-Johnson syndrome and toxic epidermal necrolysis
• Swollen lymph nodes
• Fever
• Joint pain
• General malaise
• Eosinophilia (an increase in eosinophil count)

These symptoms can be life-threatening and require immediate medical attention.

Diagnosis of HLA Hypersensitivity to Allopurinol

The HLA hypersensitivity to allopurinol (B*58:01) test is a genetic test that detects the presence of the HLA-B*58:01 variant. This variant is associated with an increased risk of hypersensitivity to allopurinol. The test is performed on a blood or saliva sample and takes about a week to obtain results.

If a patient tests positive for the HLA-B*58:01 variant, doctors will avoid prescribing allopurinol and instead opt for alternative medications.

Cost of HLA Hypersensitivity to Allopurinol (B*58:01) Test

The cost of the HLA hypersensitivity to allopurinol (B*58:01) test at DNA Labs India is INR 8000. This test is not covered by insurance, so patients will need to pay for it out of pocket.

Conclusion

HLA hypersensitivity to allopurinol can have severe and life-threatening symptoms. However, with the HLA hypersensitivity to allopurinol (B*58:01) test, doctors can identify patients at risk and avoid prescribing allopurinol. The test is a simple genetic test that can be performed on a blood or saliva sample, and the cost is INR 8000. If you have a history of hypersensitivity to allopurinol, we recommend talking to your doctor about the HLA hypersensitivity to allopurinol (B*58:01) test.

Presence of HLA B*58:01 is associated with hypersensitivity to Allopurinol therapy. Allopurinol is widely used for hyperuricemia related diseases such as Gout, Lesch- Nyhan Syndrome and recurrent urate kidney stones. Such individuals are at risk of developing Allopurinol hypersensitivity syndrome which includes Toxic Epidermal Necrolysis (TEN) or Stevens- Johnson Syndrome (SJS) and also features of eosinophilia, vasculitis and major end organ disease. Patients of Han Chinese or Thai descent are at a very high risk for developing Allopurinol hypersensitivity syndrome. Therapy should be discontinued immediately and permanently if Allopurinol hypersensitivity syndrome develops.