Short Description

Presence of HLA- B*57:01 is associated with hypersensitivity to Abacavir, a highly effective drug used to treat HIV infection and AIDS. Hypersensitivity reactions usually occur during the first 6 weeks of treatment and include skin rashes, gastrointestinal and respiratory symptoms. Fatalities have also been reported with Abacavir. This allele is also associated with 80 fold increased risk of liver injury when treated with Flucloxacillin. Although the negative predictive value of the test is high, a negative result does not preclude the development of an allergic response to Abacavir and cannot substitute for clinical vigilance whenever Abacavir is administered.

PreTest Information

No special preparation required

Detail Description

HLA Hypersensitivity to Abacavir (B*57:01) Test: Symptoms, Diagnosis, and Cost in India

Abacavir is an antiretroviral drug used to treat HIV infection. However, some people may have a hypersensitivity reaction to this drug, which can cause severe symptoms such as fever, rash, and respiratory distress. The HLA Hypersensitivity to Abacavir (B*57:01) Test is a genetic test that can determine if a person has an increased risk of developing this hypersensitivity reaction.

Symptoms of HLA Hypersensitivity to Abacavir

The symptoms of HLA Hypersensitivity to Abacavir can vary from mild to severe. Some of the common symptoms include:

• Fever
• Rash
• Nausea and vomiting
• Abdominal pain
• Shortness of breath
• Cough
• Swollen glands

In severe cases, the symptoms can progress to anaphylaxis, which is a life-threatening allergic reaction. Symptoms of anaphylaxis include difficulty breathing, swelling of the face and throat, and a rapid heartbeat.

Diagnosis of HLA Hypersensitivity to Abacavir

The HLA Hypersensitivity to Abacavir (B*57:01) Test is a genetic test that can determine if a person has an increased risk of developing a hypersensitivity reaction to Abacavir. The test involves taking a sample of blood or saliva and analyzing the DNA for the presence of the HLA-B*57:01 gene.

If the test is positive for the HLA-B*57:01 gene, the person has an increased risk of developing a hypersensitivity reaction to Abacavir. In this case, the use of Abacavir should be avoided, and alternative medications should be used.

Cost of HLA Hypersensitivity to Abacavir (B*57:01) Test in India

The cost of the HLA Hypersensitivity to Abacavir (B*57:01) Test in India can vary depending on the laboratory and location. On average, the test can cost around INR 8000.

It is important to note that the cost of the test may not be covered by insurance, and patients should check with their insurance provider before undergoing the test.

Conclusion

The HLA Hypersensitivity to Abacavir (B*57:01) Test is a genetic test that can determine if a person has an increased risk of developing a hypersensitivity reaction to Abacavir. The test can help healthcare providers avoid prescribing Abacavir to patients who have an increased risk of developing a hypersensitivity reaction. The cost of the test in India can vary, and patients should check with their insurance provider before undergoing the test.

At DNA Labs India, we offer the HLA Hypersensitivity to Abacavir (B*57:01) Test at an affordable cost. Contact us today to schedule an appointment.

Presence of HLA- B*57:01 is associated with hypersensitivity to Abacavir, a highly effective drug used to treat HIV infection and AIDS. Hypersensitivity reactions usually occur during the first 6 weeks of treatment and include skin rashes, gastrointestinal and respiratory symptoms. Fatalities have also been reported with Abacavir. This allele is also associated with 80 fold increased risk of liver injury when treated with Flucloxacillin. Although the negative predictive value of the test is high, a negative result does not preclude the development of an allergic response to Abacavir and cannot substitute for clinical vigilance whenever Abacavir is administered.