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HLA DNA TYPING FOR BONE MARROW TRANSPLANT: 10 ANTIGENS PCR Test Cost 24570 Rs
HLA DNA TYPING FOR BONE MARROW TRANSPLANT: 10 ANTIGENS PCR Test Details
HLA DNA TYPING FOR BONE MARROW TRANSPLANT: 10 ANTIGENS PCR Test cost INR:24570 symptoms diagnosis
Bone marrow transplant is a medical procedure that is performed to treat certain types of cancer and other conditions related to the blood. The procedure involves the transfer of healthy bone marrow stem cells to the patient's body to replace the damaged or diseased cells. To ensure the success of this procedure, it is essential to identify the Human Leukocyte Antigens (HLA) of the donor and the recipient. HLA DNA typing is a test that is performed to determine the compatibility of the donor and the recipient, and it is an important step in the bone marrow transplant procedure.
What is HLA DNA typing?
HLA DNA typing is a test that is performed to determine the unique genetic makeup of an individual's HLA system. The HLA system is a group of genes that are responsible for the regulation of the immune system and the recognition of foreign substances in the body. The HLA genes are inherited from both parents, and they are highly polymorphic, which means that there are many different variations of these genes within the population. HLA DNA typing involves the analysis of the DNA sequence of these genes to determine the specific HLA antigens that are present in an individual's body.
Why is HLA DNA typing important for bone marrow transplant?
Bone marrow transplant involves the transfer of stem cells from a donor to the recipient. For the transplant to be successful, the donor and the recipient must have a compatible HLA system. If the HLA system of the donor and the recipient is not compatible, the recipient's immune system will recognize the donor's cells as foreign and attack them. This can lead to a condition known as graft-versus-host disease (GVHD), which can be life-threatening. Therefore, it is essential to perform HLA DNA typing to determine the compatibility of the donor and the recipient.
How is HLA DNA typing performed?
HLA DNA typing is performed using a Polymerase Chain Reaction (PCR) test. The PCR test is a highly sensitive and specific method that can detect small amounts of DNA in a sample. The test involves the amplification of specific regions of the HLA genes using PCR technology. The amplified DNA is then sequenced, and the HLA antigens are identified based on the DNA sequence.
Symptoms of bone marrow transplant rejection
If the bone marrow transplant is not successful, the recipient's body will reject the donor's cells. The symptoms of bone marrow transplant rejection include:
- Fever
- Fatigue
- Nausea and vomiting
- Skin rash
- Diarrhea
- Shortness of breath
- Abdominal pain
Diagnosis of bone marrow transplant rejection
The diagnosis of bone marrow transplant rejection is based on a combination of clinical symptoms and laboratory tests. The laboratory tests include:
- Complete blood count (CBC)
- Bone marrow biopsy
- HLA DNA typing
- Chimerism analysis
Cost of HLA DNA typing for bone marrow transplant
The cost of HLA DNA typing for bone marrow transplant in India is INR 24570.
Conclusion
HLA DNA typing is an important test that is performed to determine the compatibility of the donor and the recipient in a bone marrow transplant procedure. The test uses PCR technology to amplify and sequence specific regions of the HLA genes to identify the HLA antigens present in an individual's body. The cost of HLA DNA typing for bone marrow transplant in India is INR 24570. If the bone marrow transplant is not successful, the recipient's body will reject the donor's cells, and the diagnosis is based on a combination of clinical symptoms and laboratory tests.
At DNA Labs India, we offer state-of-the-art HLA DNA typing services for bone marrow transplant at an affordable cost. Our team of experienced professionals uses the latest technology to ensure accurate and reliable results. Contact us today to learn more about our services.
Disclaimer: The information provided in this blog is for educational purposes only and should not be considered medical advice. Please consult with your healthcare provider for personalized medical recommendations.
This test helps to determine the extent of match between donor & recipient. In cases of bone marrow transplants it requires ideally a 100% match for all 5 A, B, C, DRB1 & DQB1 antigens. This test can also be used for Stem cell transplantation and HLA typing for Cord blood registry.
