Short Description

NGS genetic DNA test detecets for variant and mutation detection in HGF gene for Deafness, autosomal recessive type 39

PreTest Information

Clinical History of Patient who is going for EYA1 Gene Branchiootic syndrome type 1 NGS Genetic DNA Test. A Genetic Counselling session to draw a pedigree chart of family members affected with EYA1 Gene Branchiootic syndrome type 1 NGS Genetic DNA Test gene EYA9

Detail Description

HGF Gene Deafness, Autosomal Recessive Type 39: NGS Genetic DNA Test Cost INR 20,000

Deafness is a common sensory disorder that affects millions of people worldwide. It can be caused by genetic factors, environmental factors, or a combination of both. One of the genetic causes of deafness is the HGF gene, which is associated with autosomal recessive type 39 (DFNB39) deafness. This type of deafness is caused by mutations in the HGF gene, which encodes for hepatocyte growth factor (HGF).

HGF Gene and Deafness

The HGF gene is located on chromosome 7 and is responsible for encoding the hepatocyte growth factor (HGF) protein. HGF is a cytokine that is involved in the growth, differentiation, and regeneration of tissues. It is also involved in the development and maintenance of the auditory system.

DFNB39 deafness is caused by mutations in the HGF gene, which disrupt the normal functioning of the HGF protein. This disruption leads to the degeneration of the hair cells in the inner ear, which are responsible for converting sound waves into electrical signals that are sent to the brain. As a result, individuals with DFNB39 deafness have a progressive hearing loss that begins in childhood and leads to profound deafness by adulthood.

Symptoms of DFNB39 Deafness

The symptoms of DFNB39 deafness are similar to those of other types of genetic deafness. They include:

• Progressive hearing loss
• Difficulty understanding speech, especially in noisy environments
• Tinnitus (ringing in the ears)
• Difficulty localizing sounds

Diagnosis of DFNB39 Deafness

DFNB39 deafness can be diagnosed through genetic testing. The most common method of genetic testing is next-generation sequencing (NGS) of the HGF gene. NGS is a high-throughput method that allows for the rapid and accurate sequencing of DNA. This test can identify mutations in the HGF gene that are associated with DFNB39 deafness.

NGS Genetic DNA Test Cost

The cost of an NGS genetic DNA test for DFNB39 deafness is INR 20,000. This test is available at DNA Labs India, a leading genetic testing laboratory in India. The test involves the collection of a blood or saliva sample, which is then sent to the laboratory for analysis. Results are typically available within 2-3 weeks.

Conclusion

DFNB39 deafness is a rare genetic disorder that is caused by mutations in the HGF gene. It is characterized by progressive hearing loss that begins in childhood and leads to profound deafness by adulthood. Genetic testing, specifically NGS of the HGF gene, can diagnose this disorder. DNA Labs India offers this test at a cost of INR 20,000. If you or someone you know is experiencing symptoms of DFNB39 deafness, consider genetic testing to determine the cause of the hearing loss.