Short Description

PNH is an acquired clonal disorder of hemopoiesis in which patient's red cells are abnormally sensitive to lysis by normal constituents of plasma.

PreTest Information

No special preparation required

Detail Description

Ham Test Paroxysmal Nocturnal Hemoglobinuria (PNH) Screening Test

Paroxysmal Nocturnal Hemoglobinuria (PNH) is a rare and life-threatening blood disorder that affects red blood cells. It is caused by a genetic mutation that leads to the destruction of red blood cells by the body's own immune system. PNH is characterized by the presence of abnormal red blood cells called PNH cells, which are deficient in certain proteins that protect them from destruction.

Symptoms of PNH

PNH can cause a wide range of symptoms, including:

• Anemia
• Fatigue
• Shortness of breath
• Chest pain
• Abdominal pain
• Difficulty swallowing
• Back pain
• Dark urine
• Jaundice

These symptoms can vary in severity and may come and go over time. In some cases, PNH may be asymptomatic, meaning that a person may not experience any symptoms at all.

Diagnosis of PNH

PNH can be difficult to diagnose because its symptoms are similar to those of other blood disorders. However, there are several tests that can help doctors diagnose PNH, including:

• Ham test
• Flow cytometry
• Bone marrow biopsy

Ham Test

The Ham test is a screening test for PNH that measures the sensitivity of red blood cells to the complement system, which is part of the immune system. The test involves mixing a patient's red blood cells with serum containing complement and observing the cells for signs of lysis, or destruction. If the cells are sensitive to complement, they will lyse and release hemoglobin, which can be detected using a spectrophotometer.

Cost of Ham Test PNH Screening Test

The cost of the Ham test PNH screening test in India is INR 1404.

Conclusion

PNH is a rare and life-threatening blood disorder that can cause a wide range of symptoms. It can be difficult to diagnose, but the Ham test is a screening test that can help doctors identify PNH. If you are experiencing symptoms of PNH, it is important to talk to your doctor and get tested.

At DNA Labs India, we offer a range of diagnostic tests, including the Ham test PNH screening test. Our team of experienced professionals is dedicated to providing accurate and timely test results to help you get the treatment you need. Contact us today to learn more about our services.