Short Description

FLT3 (ITD, D835Y) Mutation Detection is performed using End Point PCR methodology. Sample that have to be given is Bone marrow / Peripheral blood (Transport immediately) in EDTA Vacutainer (2ml) for this test. You can expect results in 3-4 days

PreTest Information

FLT3 (ITD, D835Y) Mutation Detection can be done with a Doctor’s prescription. Prescription is not applicable for surgery and pregnancy cases or people planing to travel abroad.

Detail Description

FLT3 (ITD, D835Y) Mutation Detection: Symptoms, Diagnosis, and Cost in India

FLT3 (Fms-like tyrosine kinase 3) is a gene that plays a crucial role in the development and growth of blood cells. FLT3 mutations are common in acute myeloid leukemia (AML), a type of cancer that affects the blood and bone marrow. FLT3 mutations occur in about 30% of patients with AML and are associated with a poor prognosis.

Symptoms of FLT3 Mutations

FLT3 mutations do not usually cause any specific symptoms. However, patients with AML may experience the following symptoms:

• Fever
• Weakness and fatigue
• Weight loss
• Bone pain
• Easy bruising and bleeding
• Shortness of breath
• Swollen lymph nodes

Diagnosis of FLT3 Mutations

FLT3 mutations can be detected through genetic testing. The two most common FLT3 mutations are FLT3-ITD and FLT3-D835Y. FLT3-ITD (internal tandem duplication) involves the insertion of extra genetic material into the FLT3 gene, resulting in a longer protein that is constantly activated. FLT3-D835Y involves a change in the genetic sequence of the FLT3 gene, resulting in a protein that is always activated.

To diagnose FLT3 mutations, a sample of bone marrow or blood is collected from the patient. The sample is then sent to a laboratory for genetic testing. The test results will indicate whether the patient has FLT3 mutations and which type of mutation is present.

FLT3 Mutation Detection Cost in India

The cost of FLT3 mutation detection in India varies depending on the laboratory and the type of test performed. On average, the cost of FLT3 mutation detection ranges from INR 6,000 to INR 10,000. Some labs may also offer package deals for multiple genetic tests.

Conclusion

FLT3 mutations are common in AML and are associated with a poor prognosis. Patients with AML may experience a range of symptoms, including fever, weakness, and bone pain. FLT3 mutations can be detected through genetic testing, which involves collecting a sample of bone marrow or blood from the patient. The cost of FLT3 mutation detection in India ranges from INR 6,000 to INR 10,000.

If you suspect that you may have FLT3 mutations or have been diagnosed with AML, it is important to consult with a healthcare professional to determine the best course of treatment.

For more information on FLT3 mutation detection or other genetic testing services, contact DNA Labs India.