Test Name	FISH - ROS1 (6q22) REARRANGEMENT Test
Test type	Oncologist
Pre-test Information	Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory.
Report Delivery	Sample Daily by 4 pm; Report 4 Working days
Components
Price	₹ 8500
Method	FISH

Short Description

The c-ros oncogene 1 (ROS1), originally described in Glioblastomas, has been identified as a potential relevant therapeutic target in lung Adenocarcinoma. Crizotinib has shown in vitro activity and early evidence of clinical activity in?ÿROS1-rearranged tumors. FISH is better-suited than molecular testing to detect the spectrum of variants of ROS1 gene. It has seven chromosomes described so far in Non-Small Cell Lung Carcinoma (NSCLC).?ÿWhile molecular assays must be designed to individual and unique fusions, FISH detection encompasses all described and as yet undescribed rearrangements.

PreTest Information

Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory.

Detail Description

FISH - ROS1 (6q22) REARRANGEMENT Test Cost: INR 8500 Symptoms Diagnosis

DNA Labs India offers the FISH - ROS1 (6q22) Rearrangement Test for the diagnosis of lung cancer. This test is a highly sensitive and specific method for the detection of rearrangement of the ROS1 gene on chromosome 6q22 in tumor samples. The test is done using fluorescence in situ hybridization (FISH) technology and is available at an affordable cost of INR 8500.

What is FISH - ROS1 (6q22) Rearrangement Test?

FISH - ROS1 (6q22) Rearrangement Test is a diagnostic test that detects the rearrangement of the ROS1 gene on chromosome 6q22 in tumor samples. This test helps in the diagnosis of lung cancer and is done using fluorescence in situ hybridization (FISH) technology. In this test, the tumor sample is stained with a fluorescent probe that binds to the ROS1 gene. If the ROS1 gene is rearranged, the probe will bind to the altered gene and produce a fluorescent signal that can be visualized under a microscope.

What are the Symptoms of Lung Cancer?

The symptoms of lung cancer may include:

• Coughing, especially if it persists or becomes intense
• Chest pain that is often worse with deep breathing, coughing, or laughing
• Hoarseness
• Weight loss and loss of appetite
• Coughing up blood or rust-colored sputum (spit or phlegm)
• Shortness of breath
• Feeling tired or weak
• Infections such as bronchitis and pneumonia that don’t go away or keep coming back

How is Lung Cancer Diagnosed?

Lung cancer is diagnosed through various methods, including:

• Physical exam
• Chest X-ray
• CT scan
• Biopsy
• Bronchoscopy
• Endobronchial ultrasound
• Mediastinoscopy
• Positron emission tomography (PET) scan

Conclusion

FISH - ROS1 (6q22) Rearrangement Test is a highly sensitive and specific method for the detection of rearrangement of the ROS1 gene on chromosome 6q22 in tumor samples. This test helps in the diagnosis of lung cancer and is available at an affordable cost of INR 8500 at DNA Labs India. If you are experiencing any symptoms of lung cancer, it is important to consult with your doctor and get tested as early detection can lead to better outcomes.

The c-ros oncogene 1 (ROS1), originally described in Glioblastomas, has been identified as a potential relevant therapeutic target in lung Adenocarcinoma. Crizotinib has shown in vitro activity and early evidence of clinical activity in?ÿROS1-rearranged tumors. FISH is better-suited than molecular testing to detect the spectrum of variants of ROS1 gene. It has seven chromosomes described so far in Non-Small Cell Lung Carcinoma (NSCLC).?ÿWhile molecular assays must be designed to individual and unique fusions, FISH detection encompasses all described and as yet undescribed rearrangements.