Short Description

RET (Rearranged during transfection proto-oncogene) encodes a tyrosine kinase (TK) receptor. Translocations involving RET were first described in Papillary Thyroid Carcinoma (PTC) where somatic rearrangements result in the fusion of its TK catalytic domain with an N-terminal dimerization domain encoded by various fusion partner genes. RET rearrangements occur in approximately 1-2% of Lung Adenocarcinomas and 10-20% of Papillary Thyroid Carcinomas. Detection of RET rearrangements is useful for diagnostic classification of disease and for predicting tumor response to targeted therapy.

PreTest Information

Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory.

Detail Description

FISH - RET Gene (10q11.2) Rearrangement Test: Cost, Symptoms, and Diagnosis

DNA Labs India is a leading diagnostic center that offers a wide range of genetic tests, including the FISH - RET Gene (10q11.2) Rearrangement Test. This test is designed to identify any rearrangements that may have occurred in the RET gene, which is located on the long arm of chromosome 10. Such rearrangements are known to be associated with several types of cancer, including thyroid cancer and lung cancer.

What is the FISH - RET Gene (10q11.2) Rearrangement Test?

FISH stands for Fluorescence In Situ Hybridization, which is a technique that is used to detect and locate specific DNA sequences within a chromosome. The FISH - RET Gene (10q11.2) Rearrangement Test is a type of FISH test that is used to identify any rearrangements that may have occurred in the RET gene.

What are the Symptoms of RET Gene Rearrangement?

Symptoms of RET gene rearrangement can vary depending on the type of cancer that is associated with the rearrangement. However, some common symptoms that may indicate the presence of RET gene rearrangement include:

• Thyroid nodules or lumps
• Hoarseness or difficulty speaking
• Difficulty breathing or swallowing
• Cough that does not go away
• Chest pain

How is RET Gene Rearrangement Diagnosed?

RET gene rearrangement is typically diagnosed through a combination of imaging tests, such as ultrasound or CT scans, and biopsy. However, the FISH - RET Gene (10q11.2) Rearrangement Test can also be used to confirm the diagnosis and identify the specific type of RET gene rearrangement that is present.

What is the Cost of FISH - RET Gene (10q11.2) Rearrangement Test?

The cost of FISH - RET Gene (10q11.2) Rearrangement Test at DNA Labs India is INR 10500. This cost may vary depending on the location and other factors.

Conclusion

The FISH - RET Gene (10q11.2) Rearrangement Test is an important diagnostic tool that can help identify the presence of RET gene rearrangement, which is associated with several types of cancer. If you are experiencing any symptoms that may indicate the presence of RET gene rearrangement, it is important to consult with a healthcare professional and undergo the necessary diagnostic tests.

At DNA Labs India, we offer a wide range of genetic tests, including the FISH - RET Gene (10q11.2) Rearrangement Test, to help individuals and healthcare professionals make informed decisions about their health.

Contact us today to learn more about our services and how we can help you.

RET (Rearranged during transfection proto-oncogene) encodes a tyrosine kinase (TK) receptor. Translocations involving RET were first described in Papillary Thyroid Carcinoma (PTC) where somatic rearrangements result in the fusion of its TK catalytic domain with an N-terminal dimerization domain encoded by various fusion partner genes. RET rearrangements occur in approximately 1-2% of Lung Adenocarcinomas and 10-20% of Papillary Thyroid Carcinomas. Detection of RET rearrangements is useful for diagnostic classification of disease and for predicting tumor response to targeted therapy.