Short Description

Gene rearrangements that involve NTRK1/2/3 can generate fusion oncoproteins that contain the kinase domains of TRKA/B/C, respectively. In NSCLC, NTRK fusions are estimated to occur at a frequency of approximately 0.1% to 1%. The TRK inhibitors namely, Larotrectinib (LOXO-101) and Entrectinib (RXDX-101) are oral tyrosine kinase inhibitor that have high selectivity and potency for TRKA, TRKB, and TRKC. The detection of NTRK1/2/3 translocations by Fluorescence in situ Hybridization (FISH) may be of diagnostic and therapeutic relevance.

PreTest Information

Detail Description

FISH-NTRK 12 & 3 GENE PANEL Test: Cost, Symptoms, and Diagnosis

At DNA Labs India, we offer FISH-NTRK 12 & 3 GENE PANEL test to help diagnose cancer. This test determines the presence of specific genetic mutations that are associated with cancer, especially rare cancers and tumors.

What is FISH-NTRK 12 & 3 GENE PANEL test?

FISH-NTRK 12 & 3 GENE PANEL test is a type of genetic test that is used to detect the presence of certain genetic mutations in cancer cells. This test uses fluorescent probes to identify specific genes that are associated with cancer, especially rare cancers and tumors. The test is typically performed on a biopsy sample of the tumor tissue.

What are the symptoms of cancer?

Cancer can cause a wide range of symptoms, depending on the type and stage of the cancer. Some common symptoms of cancer include:

• Unexplained weight loss
• Fatigue
• Persistent pain
• Changes in the skin, such as a new mole or discoloration
• Changes in bowel or bladder habits
• Difficulty swallowing
• A persistent cough or hoarseness

How is cancer diagnosed?

Cancer is typically diagnosed through a combination of tests, including:

• Physical examination
• Medical history
• Blood tests
• Imaging tests, such as X-rays, CT scans, MRI scans, or PET scans
• Biopsy

What is the cost of FISH-NTRK 12 & 3 GENE PANEL test?

The cost of the FISH-NTRK 12 & 3 GENE PANEL test at DNA Labs India is INR 17550. This cost may vary depending on the location and other factors.

Conclusion

If you or a loved one is experiencing symptoms of cancer, it is important to see a doctor for diagnosis and treatment. FISH-NTRK 12 & 3 GENE PANEL test is one of the tests that may be used to help diagnose cancer, especially rare cancers and tumors. At DNA Labs India, we offer this test at a reasonable cost to help our patients get the care they need.

Gene rearrangements that involve NTRK1/2/3 can generate fusion oncoproteins that contain the kinase domains of TRKA/B/C, respectively. In NSCLC, NTRK fusions are estimated to occur at a frequency of approximately 0.1% to 1%. The TRK inhibitors namely, Larotrectinib (LOXO-101) and Entrectinib (RXDX-101) are oral tyrosine kinase inhibitor that have high selectivity and potency for TRKA, TRKB, and TRKC. The detection of NTRK1/2/3 translocations by Fluorescence in situ Hybridization (FISH) may be of diagnostic and therapeutic relevance.