Short Description

FISH is better suited than molecular testing to detect the spectrum of variants of ALK and ROS1 rearrangements. The ALK gene has more than 20 known rearrangement partner genes,?ÿwith 15 variants of the most common EML4-ALK fusion. ROS1 has seven partners described so far in NSCLC.?ÿWhile molecular assays must be designed to individual and unique fusions, FISH detection encompasses all described and as yet undescribed rearrangements.

PreTest Information

Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory.

Detail Description

FISH - NSCLC (NON-SMALL CELL LUNG CANCER) ALK1 & ROS1 Test cost INR:16000 symptoms diagnosis

Non-Small Cell Lung Cancer (NSCLC) is a type of lung cancer that accounts for approximately 85% of all lung cancer cases. It is further classified into different subtypes based on the genetic changes that occur in the cancer cells.

FISH (Fluorescence In Situ Hybridization) is a type of genetic test that can detect specific genetic changes in cancer cells. Two such genetic changes that are commonly found in NSCLC are ALK1 and ROS1 gene rearrangements.

Symptoms of NSCLC

The symptoms of NSCLC can vary depending on the location and stage of the cancer. Some common symptoms include:

• Coughing that doesn't go away
• Chest pain
• Shortness of breath
• Wheezing
• Coughing up blood
• Loss of appetite
• Unintentional weight loss
• Fatigue

Diagnosis of NSCLC

Diagnosis of NSCLC typically involves a combination of imaging tests, such as CT scans and PET scans, and biopsy to confirm the presence of cancer cells. FISH testing is a type of genetic test that can be performed on the biopsy specimen to detect specific genetic changes in the cancer cells, such as ALK1 and ROS1 gene rearrangements.

ALK1 and ROS1 FISH Testing

ALK1 and ROS1 FISH testing is a type of genetic test that can detect specific genetic changes in NSCLC cells. The test is performed on a biopsy specimen and involves using fluorescent probes to identify the presence of ALK1 or ROS1 gene rearrangements.

ALK1 and ROS1 gene rearrangements are found in a small percentage of NSCLC cases, but they are important to detect because they are associated with a higher response rate to targeted therapies.

Cost of ALK1 and ROS1 FISH Testing

The cost of ALK1 and ROS1 FISH testing in India is approximately INR 16,000. The cost may vary depending on the laboratory and location.

Conclusion

FISH testing for ALK1 and ROS1 gene rearrangements is an important tool in the diagnosis and treatment of NSCLC. If you are experiencing symptoms of lung cancer, it is important to speak with your healthcare provider about the appropriate diagnostic tests, including FISH testing, to determine the best course of treatment for your individual case.

For more information about FISH testing for NSCLC, contact DNA Labs India.

FISH is better suited than molecular testing to detect the spectrum of variants of ALK and ROS1 rearrangements. The ALK gene has more than 20 known rearrangement partner genes,?ÿwith 15 variants of the most common EML4-ALK fusion. ROS1 has seven partners described so far in NSCLC.?ÿWhile molecular assays must be designed to individual and unique fusions, FISH detection encompasses all described and as yet undescribed rearrangements.