Short Description

This test detects amplification of the MDM2 gene for classification of certain adipocytic tumors. MDM2 amplifications are frequently detected in Well differentiated Liposarcoma, which includes Atypical Lipomatous Tumor (WDL/ALT) and in Dedifferentiated Liposarcoma (DDLS). These tumors can be difficult to distinguish morphologically from other high grade sarcomas and benign tumors. Amplifications are detected infrequently in other soft tissue sarcomas, and are not detected in benign lipomas.

PreTest Information

Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory.

Detail Description

FISH - MDM2 (12q15) GENE AMPLIFICATION Test Cost INR:10500 Symptoms Diagnosis

MDM2 (12q15) gene amplification is a genetic alteration that is associated with the development of certain types of cancer, including soft tissue sarcoma and osteosarcoma. The FISH (fluorescence in situ hybridization) test is an important diagnostic tool that is used to detect this genetic alteration.

Symptoms of MDM2 (12q15) Gene Amplification

The symptoms of MDM2 (12q15) gene amplification can vary depending on the type of cancer that is present. In soft tissue sarcoma, symptoms may include:

• A lump or swelling that may be painful
• Difficulty moving the affected area
• Unexplained weight loss
• Fever

In osteosarcoma, symptoms may include:

• Pain and swelling in the affected bone
• Difficulty moving the affected limb
• Unexplained weight loss
• Fever

Diagnosis of MDM2 (12q15) Gene Amplification

The diagnosis of MDM2 (12q15) gene amplification is typically made through a combination of physical examination, imaging tests (such as x-rays, MRI, or CT scans), and laboratory tests. The FISH test is a highly sensitive and specific test that is used to detect the presence of MDM2 (12q15) gene amplification.

FISH - MDM2 (12q15) Gene Amplification Test Cost

The cost of the FISH - MDM2 (12q15) gene amplification test in India is INR 10500. This cost may vary depending on the specific laboratory or healthcare provider that is performing the test.

Conclusion

The FISH - MDM2 (12q15) gene amplification test is an important diagnostic tool that can help to identify the presence of MDM2 (12q15) gene amplification in patients with soft tissue sarcoma or osteosarcoma. If you are experiencing symptoms that may be associated with these types of cancer, it is important to speak with your healthcare provider about the possibility of undergoing this test.

At DNA Labs India, we offer a range of genetic testing services, including the FISH - MDM2 (12q15) gene amplification test. Our team of experienced professionals is committed to providing accurate and reliable results, as well as compassionate and personalized care to each and every one of our patients. Contact us today to learn more about our services and how we can help you.

This test detects amplification of the MDM2 gene for classification of certain adipocytic tumors. MDM2 amplifications are frequently detected in Well differentiated Liposarcoma, which includes Atypical Lipomatous Tumor (WDL/ALT) and in Dedifferentiated Liposarcoma (DDLS). These tumors can be difficult to distinguish morphologically from other high grade sarcomas and benign tumors. Amplifications are detected infrequently in other soft tissue sarcomas, and are not detected in benign lipomas.