Short Description

Follicular lymphomas account for 22% of Non Hodgkins lymphomas worldwide. This assay is useful to diagnose Follicular lymphoma in >75% cases and Diffuse large cell lymphomas in 25% cases.

PreTest Information

Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory.

Detail Description

FISH - FOLLICULAR LYMPHOMA (IGH/BCL2) t(14;18) Test

Follicular lymphoma is a type of non-Hodgkin lymphoma (NHL) that develops from B-lymphocytes or B-cells. It is a slow-growing cancer that often affects the lymph nodes, bone marrow, and spleen.

The FISH - FOLLICULAR LYMPHOMA (IGH/BCL2) t(14;18) Test is a diagnostic test that helps in the diagnosis of follicular lymphoma. It is a type of fluorescence in situ hybridization (FISH) test that detects the translocation between chromosomes 14 and 18. This translocation causes the overexpression of the BCL2 gene, which inhibits apoptosis or programmed cell death, leading to the survival of abnormal B-cells and the development of follicular lymphoma.

Symptoms of Follicular Lymphoma

Follicular lymphoma does not usually cause symptoms in the early stages, and it may be detected incidentally during routine blood work or imaging tests. However, as the disease progresses, the following symptoms may occur:

• Enlarged lymph nodes, especially in the neck, armpit, or groin
• Abdominal pain or swelling
• Loss of appetite
• Unintentional weight loss
• Fatigue
• Night sweats
• Fever
• Itchy skin

Diagnosis of Follicular Lymphoma

To diagnose follicular lymphoma, your doctor may conduct the following tests and procedures:

• Physical exam
• Blood tests
• Imaging tests, such as X-rays, CT scans, or PET scans
• Lymph node biopsy
• Bone marrow biopsy

The FISH - FOLLICULAR LYMPHOMA (IGH/BCL2) t(14;18) Test is a specialized test that can detect the chromosomal abnormality that is specific to follicular lymphoma. It can be performed on a blood or bone marrow sample.

Cost of FISH - FOLLICULAR LYMPHOMA (IGH/BCL2) t(14;18) Test

The cost of the FISH - FOLLICULAR LYMPHOMA (IGH/BCL2) t(14;18) Test in India is INR 9,000. However, the cost may vary depending on the location of the laboratory and other factors.

Conclusion

The FISH - FOLLICULAR LYMPHOMA (IGH/BCL2) t(14;18) Test is an important diagnostic tool for the detection of follicular lymphoma. It is a specialized test that detects the chromosomal abnormality that is specific to this type of cancer. If you are experiencing any symptoms of follicular lymphoma or have been diagnosed with this condition, talk to your doctor about whether the FISH test is right for you.

At DNA Labs India, we offer a range of diagnostic tests for various types of cancer, including the FISH - FOLLICULAR LYMPHOMA (IGH/BCL2) t(14;18) Test. Our laboratory is equipped with state-of-the-art technology and staffed by highly trained professionals. Contact us today to learn more about our services and how we can assist you in your healthcare needs.

Follicular lymphomas account for 22% of Non Hodgkins lymphomas worldwide. This assay is useful to diagnose Follicular lymphoma in >75% cases and Diffuse large cell lymphomas in 25% cases.