Short Description

NGS genetic DNA test detecets for variant and mutation detection in FASLG gene for Autoimmune lymphoproliferative syndrome type 1B

PreTest Information

Clinical History of Patient who is going for FASLG Gene Autoimmune lymphoproliferative syndrome type 1B NGS Genetic DNA Test. A Genetic Counselling session to draw a pedigree chart of family members affected with FASLG Gene Autoimmune lymphoproliferative syndrome type 1B NGS Genetic DNA Test gene FASLG

Detail Description

FASLG Gene and Autoimmune Lymphoproliferative Syndrome Type 1B: Understanding Symptoms, Diagnosis, and NGS Genetic DNA Test Cost

Autoimmune Lymphoproliferative Syndrome (ALPS) is a rare genetic disorder that affects the immune system. It is caused by mutations in certain genes that regulate cell death, leading to the accumulation of lymphocytes (a type of white blood cell) in the body. One of the genes associated with ALPS is the FASLG gene, which is responsible for producing a protein called FAS ligand. Mutations in the FASLG gene can lead to ALPS Type 1B, a subtype of the disorder.

Symptoms of ALPS Type 1B

ALPS Type 1B is characterized by the following symptoms:

• Enlarged lymph nodes, spleen, and liver
• Recurrent infections
• Autoimmune disorders such as autoimmune hemolytic anemia, thrombocytopenia, and neutropenia
• Lymphoma (cancer of the lymphatic system)

These symptoms can vary in severity and may develop at different stages of life. In some cases, they may only appear in early childhood, while in others they may not manifest until adulthood.

Diagnosis of ALPS Type 1B

ALPS Type 1B is a rare disorder, and diagnosis requires a combination of clinical evaluation and genetic testing. A doctor may suspect ALPS Type 1B if a patient presents with the symptoms listed above. The diagnosis can be confirmed through genetic testing, which involves analyzing a patient's DNA to identify mutations in the FASLG gene.

NGS Genetic DNA Test Cost for ALPS Type 1B

Next-generation sequencing (NGS) is a type of genetic testing that allows for the simultaneous analysis of multiple genes. It is a powerful tool for diagnosing genetic disorders such as ALPS Type 1B. The cost of NGS genetic DNA testing for ALPS Type 1B in India is approximately INR 20,000.

NGS testing involves collecting a sample of DNA, usually through a blood or saliva sample, and analyzing it using specialized equipment. The results of the test can help doctors make an accurate diagnosis and develop an appropriate treatment plan for the patient.

Conclusion

ALPS Type 1B is a rare genetic disorder that can cause a range of symptoms, including enlarged lymph nodes, recurrent infections, and autoimmune disorders. Diagnosis requires a combination of clinical evaluation and genetic testing, including NGS genetic DNA testing. The cost of NGS testing for ALPS Type 1B in India is approximately INR 20,000. If you suspect that you or a loved one may have ALPS Type 1B, it is important to seek medical attention and undergo appropriate testing and treatment.

At DNA Labs India, we offer NGS genetic DNA testing for ALPS Type 1B and other genetic disorders. Our team of experienced genetic counselors and scientists can guide you through the testing process and provide you with the support you need. Contact us today to learn more.