Short Description

NGS genetic DNA test detecets for variant and mutation detection in EPCAM gene for Colorectal cancer, hereditary nonpolyposis type 8

PreTest Information

Clinical History of Patient who is going for EPCAM Gene Colorectal cancer, hereditary nonpolyposis type 8 NGS Genetic DNA Test. A Genetic Counselling session to draw a pedigree chart of family members affected with EPCAM Gene Colorectal cancer, hereditary nonpolyposis type 8 NGS Genetic DNA Test gene EPCAM

Detail Description

EPCAM Gene and Hereditary Nonpolyposis Colorectal Cancer - Everything You Need to Know

Colorectal cancer is one of the most common cancers in the world, with over 1.9 million new cases diagnosed every year. In India, it is the fourth most common cancer in men and the third most common in women. Hereditary nonpolyposis colorectal cancer (HNPCC) is a type of colorectal cancer that is caused by genetic mutations. One of the genes that have been linked to HNPCC is the EPCAM gene. In this blog post, we will take a closer look at the EPCAM gene, HNPCC, and the NGS genetic DNA test that can help diagnose this condition.

The EPCAM Gene and HNPCC

The EPCAM gene is located on chromosome 2 and is responsible for producing a protein called epithelial cell adhesion molecule. This protein is involved in cell adhesion, cell signaling, and cell differentiation. Mutations in the EPCAM gene have been linked to HNPCC, also known as Lynch syndrome. HNPCC is an inherited condition that increases the risk of developing colorectal cancer, as well as other cancers such as endometrial, ovarian, and stomach cancer. Individuals with HNPCC have a 50-80% lifetime risk of developing colorectal cancer.

Symptoms and Diagnosis of HNPCC

The symptoms of HNPCC are similar to those of sporadic colorectal cancer and include abdominal pain, changes in bowel habits, rectal bleeding, and weight loss. However, individuals with HNPCC tend to develop colorectal cancer at a younger age and may have a family history of colorectal cancer or other HNPCC-associated cancers.

Diagnosis of HNPCC involves genetic testing to identify mutations in the EPCAM gene or other genes associated with HNPCC. The most common method of genetic testing for HNPCC is next-generation sequencing (NGS), which allows for the simultaneous analysis of multiple genes. NGS can detect mutations in the EPCAM gene and other genes associated with HNPCC with high accuracy.

NGS Genetic DNA Test for HNPCC

The cost of the NGS genetic DNA test for HNPCC in India varies depending on the laboratory and the specific genes being tested. At DNA Labs India, the cost of the NGS genetic DNA test for HNPCC, including the EPCAM gene, is INR 20,000.

The NGS genetic DNA test for HNPCC is a non-invasive test that involves taking a sample of DNA from the individual being tested, usually through a blood sample. The DNA is then analyzed using NGS technology to identify mutations in the EPCAM gene and other genes associated with HNPCC. The test results can help individuals and their healthcare providers make informed decisions about cancer prevention and treatment.

Conclusion

HNPCC is a hereditary condition that increases the risk of developing colorectal cancer and other cancers. The EPCAM gene is one of the genes associated with HNPCC, and mutations in this gene can be detected through NGS genetic DNA testing. At DNA Labs India, the cost of the NGS genetic DNA test for HNPCC, including the EPCAM gene, is INR 20,000. If you have a family history of colorectal cancer or other HNPCC-associated cancers, talk to your healthcare provider about genetic testing for HNPCC.