Short Description

Dihydropyrimidine dehydrogenase (DPD) enzyme is responsible for the detoxifying metabolism of fluoropyrimidines, a class of drugs that includes 5-Fluorouracil, Capecitabine, and Tegafur. Genetic variations within the DPD gene can lead to reduced or absent DPD activity, and individuals who are heterozygous or homozygous for these variations may have partial or complete DPD deficiency an estimated 0.2% of individuals have complete DPD deficiency. Those with partial or complete DPD deficiency have a significantly increased risk of severe or even fatal drug toxicities when treated with fluoropyrimidines examples of toxicities include myelosuppression, neurotoxicity and hand-foot syndrome.

PreTest Information

Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory.

Detail Description

DPD Gene Mutations (5-FU Toxicity) Detection Test Cost INR 9828: Symptoms and Diagnosis

DPD gene mutations can cause 5-fluorouracil (5-FU) toxicity, which is a serious side effect of chemotherapy treatment. It is important to detect these mutations early to prevent toxicity and ensure successful treatment. DNA Labs India offers a DPD gene mutations detection test at a cost of INR 9828. In this blog, we will discuss the symptoms and diagnosis of DPD gene mutations.

Symptoms of DPD Gene Mutations

DPD gene mutations can cause a range of symptoms, including:

• Nausea and vomiting
• Diarrhea
• Mouth sores
• Fever
• Low white blood cell count
• Hand-foot syndrome (redness, swelling, and pain on the palms of the hands and soles of the feet)
• Neuropathy (tingling or numbness in the hands and feet)

If you experience any of these symptoms during chemotherapy treatment, it is important to speak with your doctor immediately.

Diagnosis of DPD Gene Mutations

The DPD gene mutations detection test offered by DNA Labs India can determine if you have a DPD gene mutation that could cause 5-FU toxicity. The test involves a simple blood or saliva sample. The sample is analyzed in a laboratory to determine if you have any mutations in the DPD gene.

If you are undergoing chemotherapy treatment, your doctor may recommend this test to ensure that you are not at risk for 5-FU toxicity. If you have a DPD gene mutation, your doctor may adjust your chemotherapy treatment to prevent toxicity and ensure successful treatment.

Conclusion

DPD gene mutations can cause serious side effects during chemotherapy treatment. It is important to detect these mutations early to prevent toxicity and ensure successful treatment. DNA Labs India offers a DPD gene mutations detection test at a cost of INR 9828. If you are undergoing chemotherapy treatment, speak with your doctor about the importance of this test.

Remember, early detection is key to successful treatment!