Short Description

NGS genetic DNA test detecets for variant and mutation detection in CYP2C19 gene for CYP2C19 related poor drug metabolism

PreTest Information

Clinical History of Patient who is going for CYP2C19 Gene CYP2C19 related poor drug metabolism NGS Genetic DNA Test A Genetic Counselling session to draw a pedigree chart of family members affected with CYP2C19 related poor drug metabolism

Detail Description

CYP2C19 Gene and Poor Drug Metabolism: Understanding the Role of NGS Genetic DNA Test

Drug metabolism is the process by which drugs are broken down and eliminated from the body. The effectiveness of drugs in treating diseases and disorders can be influenced by the genetic makeup of an individual. One of the genes that play a significant role in drug metabolism is the CYP2C19 gene. Understanding the function of this gene and the implications of its variants on drug metabolism can help individuals and healthcare providers make informed decisions regarding drug therapies.

What is the CYP2C19 Gene?

The CYP2C19 gene is responsible for encoding a liver enzyme that plays a crucial role in the metabolism of drugs, including antiplatelet agents, antidepressants, and proton pump inhibitors. The enzyme is responsible for breaking down these drugs into their active or inactive metabolites, which are then eliminated from the body. The activity of the CYP2C19 enzyme can vary among individuals due to genetic variations.

CYP2C19 Related Poor Drug Metabolism

Genetic variations in the CYP2C19 gene can result in poor drug metabolism, leading to an increased risk of adverse drug reactions or therapeutic failure. Individuals who have reduced CYP2C19 enzyme activity are known as poor metabolizers. Poor metabolizers may require a lower dosage of drugs metabolized by CYP2C19 or alternative therapies to achieve optimal therapeutic outcomes.

NGS Genetic DNA Test for CYP2C19 Gene

Next-generation sequencing (NGS) genetic DNA testing is a powerful diagnostic tool that can identify genetic variations in the CYP2C19 gene. The test can detect single nucleotide polymorphisms (SNPs) that affect the function of the CYP2C19 enzyme and provide valuable information regarding drug metabolism. The test results can help healthcare providers tailor drug therapies to the patient's genetic profile, ensuring optimal therapeutic outcomes and reducing the risk of adverse drug reactions.

Symptoms and Diagnosis

Genetic variations in the CYP2C19 gene may not present with any symptoms. However, poor drug metabolism can lead to adverse drug reactions or therapeutic failure. Patients who experience adverse drug reactions or do not respond to standard therapies may benefit from genetic testing for the CYP2C19 gene. The test can help identify genetic variations that may be responsible for poor drug metabolism and guide alternative drug therapies.

The Cost of NGS Genetic DNA Test for CYP2C19 Gene

The cost of NGS genetic DNA testing for the CYP2C19 gene may vary depending on the provider. At DNA Labs India, the cost of the test is INR 20,000. The test is non-invasive and requires a simple blood or saliva sample. The test results are typically available within 2-3 weeks, and the report includes information on genetic variations in the CYP2C19 gene and their implications on drug metabolism.

Conclusion

Genetic variations in the CYP2C19 gene can significantly impact drug metabolism, leading to adverse drug reactions or therapeutic failure. NGS genetic DNA testing is a valuable diagnostic tool that can identify genetic variations in the CYP2C19 gene and guide alternative drug therapies. The cost of the test at DNA Labs India is INR 20,000, and the results are typically available within 2-3 weeks. Understanding the role of the CYP2C19 gene in drug metabolism can help healthcare providers tailor drug therapies to the patient's genetic profile, ensuring optimal therapeutic outcomes and reducing the risk of adverse drug reactions.

The CYP2C19 gene encodes an enzyme known as cytochrome P450 2C19, which is responsible for metabolizing a variety of medications, including certain drugs used for treating various conditions. Genetic variations in the CYP2C19 gene can lead to differences in how individuals metabolize these medications, potentially affecting their effectiveness and safety.